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Cyclamic acid

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Name

Cyclamic acid

EINECS 202-898-1
CAS No. 100-88-9 Density 1.32g/cm3
PSA 74.78000 LogP 2.18320
Solubility Soluble SOLVENT Melting Point 165 - 170 C (Decomposes)
Formula C6H13 N O3 S Boiling Point °Cat760mmHg
Molecular Weight 179.24 Flash Point °C
Transport Information 25kgs Appearance white crystals
Safety Suspected human carcinogen producing bladder tumors. Poison by intravenous route. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of SOx and NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 100-88-9 (Cyclamic acid) Hazard Symbols UN NO.
Synonyms

Cyclohexanesulfamicacid (6CI,7CI,8CI);Sulfamic acid, cyclohexyl- (9CI);Cyclamate;Cyclamic acid;Cyclohexylamidosulfuric acid;Cyclohexylaminesulfonic acid;Cyclohexylsulfamicacid;Hexamic acid;N-Cyclohexylsulfamic acid;NSC 220327;Polycat 200;

Article Data 21

Cyclamic acid Synthetic route

108-91-8

cyclohexylamine

100-88-9

cyclohexylsulfamic acid

Conditions
ConditionsYield
With chlorosulfonic acid In chloroform for 8h; Ambient temperature;72%
With chlorosulphuric acid; chloroform
With chlorosulfonic acid
With chlorosulfonic acid In acetonitrile at 20℃; for 2h;
3173-53-3

Cyclohexyl isocyanate

100-88-9

cyclohexylsulfamic acid

Conditions
ConditionsYield
With sulfuric acid; sulfur trioxide
2211-64-5

N-cyclohexyl-hydroxylamine

100-88-9

cyclohexylsulfamic acid

Conditions
ConditionsYield
With sulfur dioxide; benzene
1122-60-7

1-nitrocyclohexane

100-88-9

cyclohexylsulfamic acid

Conditions
ConditionsYield
With sodium dithionite; water; sodium phosphate
108-91-8

cyclohexylamine

sodium chloro sulfate

sodium chloro sulfate

100-88-9

cyclohexylsulfamic acid

100-88-9

cyclohexylsulfamic acid

1620401-56-0

(R)-6-methylamino-2-methylheptene

(R)-isometheptene cyclamate

Conditions
ConditionsYield
In ethanol at -20℃; Solvent; Temperature;100%
100-88-9

cyclohexylsulfamic acid

C43H51N7O9S2

(x)C6H13NO3S*C43H51N7O9S2

Conditions
ConditionsYield
In methanol at 20℃;95.6%
100-88-9

cyclohexylsulfamic acid

5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one N-cyclohexylsulfamate

Conditions
ConditionsYield
In ethanol; water at -15 - 80℃;95.2%
706779-91-1

N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide

100-88-9

cyclohexylsulfamic acid

C25H34FN3O2*H2O*C6H13NO3S

Conditions
ConditionsYield
In ethyl acetate at 20 - 42℃; for 5h;93.7%
100-88-9

cyclohexylsulfamic acid

302962-49-8

dasatanib

N-(2-chloro-6-methylphenyl)-2-[6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-ylamino]-1,3-thiazole-5-carboxamide monocyclamate salt

Conditions
ConditionsYield
In methanol at 70℃;93.4%

Cyclamic acid Chemical Properties

Chemistry informtions about  Cyclamic acid (100-88-9) is:
IUPAC Name: (2E)-2-hydroxyimino-1-phenylpropan-1-one ; -hydroxyimino-1-phenylpropan-1-one
Synonyms: Cyclohexanesulphamic acid ; cyclohexanesulphamicacid ; Cyclohexylamidosulfuric acid ; cyclohexylamidosulfuricacid ; Cyclohexylamidosulphuric acid ; cyclohexylamidosulphuricacid ; Cyclohexylaminesulfonic acid ; cyclohexylaminesulfonicacid
MF: C6H13NO3S
MW: 179.24
EINECS: 202-898-1
Melting Point:  ~180 °C (dec.)
Density: 1.32 g/cm3
Following is the molecular structure of  Cyclamic acid (100-88-9) is:

Cyclamic acid Uses

The sodium and calcium salts of  Cyclamic acid (100-88-9) are used as artificial sweeteners under the name cyclamate.This Chemical is banned in the USA and other countries for use as a sweetener. In the UK it used to be banned, but now it is allowed.This is also sometimes considered to be a carcinogen.

Cyclamic acid Toxicity Data With Reference

Organism

Test

Type

Route

Reported Dose

(Normalized

Dose)

Effect

Source

mouse

LD50

intravenous

180mg/kg

(180mg/kg)

 

U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01774,

mouse

LD50

oral

680mg/kg

(680mg/kg)

Behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory stimulation gastrointestinal: changes in structure or function of salivary glands

National Technical Information Service. Vol. OTS0540890,

rat

LD50

intravenous

4gm/kg

(4000mg/kg)

 

American Journal of the Medical Sciences. Vol. 225, Pg. 551, 1953.

rat

LD50

oral

12gm/kg

(12000mg/kg)

 

American Journal of the Medical Sciences. Vol. 225, Pg. 551, 1953.

Cyclamic acid Safety Profile

Safety Statements:
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: GV6950000

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