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| Name |
Cyclopenthiazide |
EINECS | 212-012-5 |
| CAS No. | 742-20-1 | Density | 1.471 g/cm3 |
| PSA | 135.12000 | LogP | 4.92630 |
| Solubility | soluble in alcohol, ether, acetone, chloroform-soluble | Melting Point |
238-242ºC |
| Formula | C13H18 Cl N3 O4 S2 | Boiling Point | 605.6 °C at 760 mmHg |
| Molecular Weight | 379.889 | Flash Point | 320.1 °C |
| Transport Information | N/A | Appearance | crystals |
| Safety | Poison by intravenous route. An antihypertensive agent. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxide;6-Chloro-3-(cyclopentylmethyl)-3,4-dihydro-7-sulfamyl-2H-1,2,4-benzothiadiazine1,1-dioxide;6-Chloro-3-cyclopentylmethyl-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dioxide; Benesal; Ciba 8341-Su; Cyclomethiazide; Cyclometiazid;Cyclopenthiazide; Cyclopentiazid; NSC 107679; Navidreks; Navidrex; Navidrix;Salimed; Salimid; Salurilo-C; Su 8341; Tsiklometiazid; Ultra-Minzil |
Cyclopenthiazide Chemical Properties
Molecular Formula: C13H18ClN3O4S2
Molar mass: 379.88 g/mol
EINECS: 212-012-5
Density: 1.471 g/cm3
Flash Point: 320.1 °C
Index of Refraction: 1.6
Boiling Point: 605.6 °C at 760 mmHg
Vapour Pressure: 1.29E-14 mmHg at 25 °C
Appearance: White powder, odorless, almost tasteless
Solubility: Soluble in Ethanol , Ethyl ether , Acetone ; slightly soluble in Chloroform ; insoluble in water
Product categories of Cyclopenthiazide (CAS NO.742-20-1): Active Pharmaceutical Ingredients
Structure of Cyclopenthiazide (CAS NO.742-20-1):
XLogP3-AA: 1.3
H-Bond Donor: 3
H-Bond Acceptor: 7
IUPAC Name: 6-Chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,
4]thiadiazine-7-sulfonamide
Canonical SMILES: C1CCC(C1)CC2NC3=CC(=C(C=C3S(=O)(=O)N2)S(=O)(=O)N)Cl
InChI: InChI=1S/C13H18ClN3O4S2/c14-9-6-10-12(7-11(9)22(15,18)19)23(20,
21)17-13(16-10)5-8-3-1-2-4-8/h6-8,13,16-17H,1-5H2,(H2,15,18,19)
InChIKey: BKYKPTRYDKTTJY-UHFFFAOYSA-N
Cyclopenthiazide Uses
Cyclopenthiazide (CAS NO.742-20-1) has been used for the treatment of edema and hypertension.
Cyclopenthiazide Production
Cyclopenthiazide (CAS NO.742-20-1) has been derived the cyclization of Acetaldehyde and 4,6-Cyclopentyl - 2-sulfonamide -3 - chloroaniline .
Cyclopenthiazide Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 232mg/kg (232mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 325, 1961. | |
| mouse | LD50 | oral | > 1gm/kg (1000mg/kg) | Drugs in Japan Vol. 6, Pg. 314, 1982. | |
| rat | LD50 | intravenous | 142mg/kg (142mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 131, Pg. 325, 1961. | |
| rat | LD50 | oral | 1gm/kg (1000mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 21, Pg. 775, 1979. |
Cyclopenthiazide Safety Profile
Poison by intravenous route. An antihypertensive agent. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−.
Cyclopenthiazide Specification
Cyclopenthiazide ,its cas register number is 742-20-1. It also can be called Tsiklometiazid ; Benesal ; 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(cyclopentylmethyl)-3,4-dihydro-, 1,1-dioxide ; 3-Cyclopentylmethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide ; 6-Chloro-3-cyclopentylmethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-Dioxide and 6-Chloro-3-(cyclopentylmethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide .
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