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CAS No.: | 121-30-2 |
---|---|
Name: | 4-Amino-6-chlorobenzene-1,3-disulfonamide |
Article Data: | 57 |
Molecular Structure: | |
Formula: | C6H8ClN3O4S2 |
Molecular Weight: | 285.732 |
Synonyms: | m-Benzenedisulfonamide,4-amino-6-chloro- (8CI);1-Amino-5-chloro-2,4-benzenedisulfonamide;3-Chloro-4,6-disulfamoylaniline;4-Amino-6-chloro-1,3-benzenedisulfonamide;4-Amino-6-chloro-m-benzenedisulfonamide;5-Chloro-2,4-disulfamoylaniline;Chloraminophenamide;Chloroaminophenamide;Idorese;NSC 93772;Salamid;Salamide;Salamide (diuretic);Salmid;Su 5683; |
EINECS: | 204-463-1 |
Density: | 1.768 g/cm3 |
Melting Point: | 254.5 ºC |
Boiling Point: | 614.4 ºC at 760 mmHg |
Flash Point: | 325.4 ºC |
Appearance: | white to almost white crystalline powder |
Hazard Symbols: | T |
Risk Codes: | 23/24-33 |
Safety: | 28-36/37 |
PSA: | 163.10000 |
LogP: | 3.36040 |
Conditions | Yield |
---|---|
With ammonia |
d-ethiazide
A
chloraminophenamide
l-ethiazide
Conditions | Yield |
---|---|
With water at 37℃; phosphate buffer (pH: 7.4); or with human serum albumin; | |
With water at 37℃; Rate constant; phosphate buffer (pH: 7.4); or with human serum albumin; |
l-ethiazide
A
chloraminophenamide
d-ethiazide
Conditions | Yield |
---|---|
With water at 37℃; phosphate buffer (pH: 7.4); or with human serum albumin; | |
With water at 37℃; Rate constant; phosphate buffer (pH: 7.4); or with human serum albumin; |
methanol
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
A
chloraminophenamide
B
4-amino-1,3-benzenedisulfonamide
E
3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
F
6-methoxy-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
Conditions | Yield |
---|---|
In water Product distribution; Mechanism; Irradiation; multistep reaction, photholytic decomposition; also in pure MeOH; effect of O2; |
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
chloraminophenamide
Conditions | Yield |
---|---|
In methanol for 2160h; Product distribution; Ambient temperature; stability study; further temperature, further solvent; | |
With sodium hydroxide at 95℃; for 1h; | |
With sodium hydroxide at 80℃; for 3.5h; | |
With hydrogenchloride In methanol; propan-1-ol; water for 80h; Kinetics; |
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
A
chloraminophenamide
B
formaldehyd
Conditions | Yield |
---|---|
In ethanol at 90℃; for 528h; Equilibrium constant; Kinetics; Thermodynamic data; other temperature and time; |
Conditions | Yield |
---|---|
pyrographite hydrolysis of benzothiadiazines; | |
pyrographite hydrolysis; | |
With water In ethanol at 35℃; Kinetics; Temperature; Solvent; pH-value; Concentration; |
Lactose
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
A
chloraminophenamide
Conditions | Yield |
---|---|
In water at 60℃; for 336000h; pH=5.2; Substitution; |
d-ethiazide
chloraminophenamide
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: water / 37 °C / phosphate buffer (pH: 7.4); or with human serum albumin 2: water / 37 °C / phosphate buffer (pH: 7.4); or with human serum albumin View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: ClSO3H 2: NH3 View Scheme | |
Multi-step reaction with 2 steps 1: ClSO3H, NaCl / 150 °C 2: NH3 View Scheme |
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The Molecular Structure of 1,3-Benzenedisulfonamide,4-amino-6-chloro- (CAS NO.121-30-2):
Empirical Formula: C6H8ClN3O4S2
Molecular Weight: 285.7284
IUPAC Name: 4-Amino-6-chlorobenzene-1,3-disulfonamide
Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
Nominal Mass: 285 Da
Average Mass: 285.7284 Da
Monoisotopic Mass: 284.964473 Da
Index of Refraction: 1.666
Molar Refractivity: 60.07 cm3
Molar Volume: 161.5 cm3
Surface Tension: 81.6 dyne/cm
Density: 1.768 g/cm3
Flash Point: 325.4 °C
Enthalpy of Vaporization: 91.17 kJ/mol
Boiling Point: 614.4 °C at 760 mmHg
Vapour Pressure: 4.98E-15 mmHg at 25 °C
Melting Point: 254.5 °C
log P (octanol-water): -0.41
Atmospheric OH Rate Constant: 3.46E-12 cm3/molecule-sec at 25 °C
InChI: InChI=1/C6H8ClN3O4S2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2H,8H2,(H2,9,11,12)(H2,10,13,14)
Smiles: O=S(=O)(N)c1c(N)cc(c(S(=O)(=O)N)c1)Cl
1,3-Benzenedisulfonamide,4-amino-6-chloro- (CAS NO.121-30-2) is used as pharmaceutical intermediates,and also can be used for synthesis of hydrochlorothiazide and other bulk drugs.
Hazard Codes: T
Risk Statements: 23/24-33
R23/24/25: Toxic by inhalation, in contact with skin and if swallowed
R33: Danger of cumulative effects
Safety Statements: 28-36/37
S28: After contact with skin, wash immediately with plenty of soap-suds
S36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
1,3-Benzenedisulfonamide,4-amino-6-chloro- (CAS NO.121-30-2) is also called as 4-Amino-6-chloro-1,3-benzenedisulfonamide ; Chloraminophenamide ; 3-Chloro-4,6-disulfamoylaniline ; 4-Amino-6-chloro-m-benzenedisulfonamide ; 5-Chloro-2,4-disulfamoylaniline ; Chloraminophenamide ; Chloroaminophenamide ; 4-Amino-6-chlorobenzene-1,3-disulphonamide ; m-Benzenedisulfonamide, 4-amino-6-chloro- (8CI) .