NTP 10th Report on Carcinogens. IARC Cancer Review: Group 1 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 182.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 , 1981,p. 165.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 26 , 1981,p. 165.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 , 1975,p. 135.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 9 , 1975,p. 135.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Studies (ipr); Clear Evidence: mouse, rat RRCRBU    Recent Results in Cancer Research. 52 (1975),1. . EPA Genetic Toxicology Program.

The Cyclophosphoramide with CAS registry number of 50-18-0 is also called 2H-1,3,2-Oxazaphosphorin-2-amine,N,N-bis(2-chloroethyl)tetrahydro-,2-oxide. The IUPAC name is N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide. Its EINECS registry number is 200-015-4. In addition, the formula is C₇H₁₅Cl₂N₂O₂P and the molecular weight is 261.085961. What's more, it is stable and incompatible with oxidizing agents. But it is sensitive to light.

Physical properties about this chemical are: (1)ACD/LogP: 0.23; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0.23; (4)ACD/LogD (pH 7.4): 0.23; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 31.69; (8)ACD/KOC (pH 7.4): 31.76; (9)#H bond acceptors: 4; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 5; (12)Polar Surface Area: 42.59 Å²; (13)Index of Refraction: 1.505; (14)Molar Refractivity: 58.09 cm³; (15)Molar Volume: 195.6 cm³; (16)Polarizability: 23.03 ×10^-24cm³; (17)Surface Tension: 44.3 dyne/cm; (18)Density: 1.33 g/cm³; (19)Flash Point: 157.1 °C; (20)Enthalpy of Vaporization: 57.92 kJ/mol; (21)Boiling Point: 336.1 °C at 760 mmHg ; (22)Vapour Pressure: 0.000115 mmHg at 25°C.

Uses of Cyclophosphoramide: it can treat many diseases such as malignant lymphoma, multiple myeloma, lymphocytic leukemia, cervical cancer, prostate cancer, colon cancer, bronchial cancer, solid tumors, rheumatoid arthritis and autoimmune diseases. In addition, it can be used to get 3-chlorocyclophosphamide. This reaction will need reagent aq.sodium hypochlorite and solvent CHCl₃. The reaction time is 18 hours and the yield is about 87%.

When you are using this chemical, please be cautious about it as the following:
You should avoid contact with skin and eyes and should not breathe dust.

You can still convert the following datas into molecular structure:
(1)SMILES: O=P1(OCCCN1)N(CCCl)CCCl
(2)InChI: InChI=1/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12)
(3)InChIKey: CMSMOCZEIVJLDB-UHFFFAOYAB

The toxicity data is as follows: