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| Name |
Desonide |
EINECS | 211-351-6 |
| CAS No. | 638-94-8 | Density | 1.3 g/cm3 |
| PSA | 93.06000 | LogP | 2.32670 |
| Solubility | N/A | Melting Point |
274 - 275oC |
| Formula | C24H32O6 | Boiling Point | 580.1 °C at 760 mmHg |
| Molecular Weight | 416.514 | Flash Point | 196.9 °C |
| Transport Information | N/A | Appearance | Powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Prenacid;Desilux;Pregna-1,4-diene-3,20-dione,11,21- dihydroxy-16,17-[(1-methylethylidene)bis- (oxy)]-,(11a,16R)-;Topifug;Locapred;Tridesilon;Flusemidon;Hamiltoderm;Desonide [USAN:BAN:INN];Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (11beta,16alpha)-;Apolar;Otic Tridesilon;Steroderm;Prednisolone-16,17-acetonide, 16-alpha-hydroxy-;DesOwen;Tridesonit;Sterax;Desonidum [INN-Latin];Budesonide acetonide; |
Desonide Synthetic route
| Conditions | Yield |
|---|---|
| With boron trifluoride In tetrahydrofuran; acetonitrile at -5 - 10℃; Inert atmosphere; | 85% |
| With methanesulfonic acid at -10℃; for 0.133333h; Temperature; |
- 638-94-8
desonide
| Conditions | Yield |
|---|---|
| With sodium hydroxide In methanol at 30℃; for 0.666667h; Temperature; Inert atmosphere; Large scale; | 81% |
- 13951-70-7
desonide
- 638-94-8
desonide
| Conditions | Yield |
|---|---|
| With perchloric acid; acetone |
- 25092-25-5
11β,16α,17α,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide 21-acetate
- 638-94-8
desonide
| Conditions | Yield |
|---|---|
| With sodium hydroxide In methanol; dichloromethane at -5 - 5℃; for 2h; Inert atmosphere; | 8.60 g |
- 37413-91-5
2-((10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,10,12,13,14,15-octahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
- 638-94-8
desonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: formic acid; potassium permanganate / acetone; water / 0.5 h / -7 - -3 °C / Industrial scale 2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / water; tetrahydrofuran / 1 h / -8 - -4 °C / Industrial scale 3: chromium(III) chloride hexahydrate; zinc; mercaptoacetic acid / N,N-dimethyl-formamide; dimethyl sulfoxide / 1 h / -10 °C / Inert atmosphere; Industrial scale 4: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere 5: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere View Scheme |
- 77017-20-0
16α,17α,21-trihydroxypregna-1,4,9(11)-triene-3,20-dione-21-acetate
- 638-94-8
desonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; perchloric acid / water; tetrahydrofuran / 1 h / -8 - -4 °C / Industrial scale 2: chromium(III) chloride hexahydrate; zinc; mercaptoacetic acid / N,N-dimethyl-formamide; dimethyl sulfoxide / 1 h / -10 °C / Inert atmosphere; Industrial scale 3: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere 4: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere View Scheme |
- 91160-89-3
9α-bromo-11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate
- 638-94-8
desonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: chromium(III) chloride hexahydrate; zinc; mercaptoacetic acid / N,N-dimethyl-formamide; dimethyl sulfoxide / 1 h / -10 °C / Inert atmosphere; Industrial scale 2: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere 3: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere View Scheme |
- 86401-80-1
11β,16α,17α,21-tetrahydroxypregnane-1,4-diene-3,20-dione-21-acetate
- 638-94-8
desonide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: perchloric acid / 1.5 h / 26 - 35 °C / Inert atmosphere 2: sodium hydroxide / methanol; dichloromethane / 2 h / -5 - 5 °C / Inert atmosphere View Scheme |
| Conditions | Yield |
|---|---|
| With potassium carbonate In acetone for 1.5h; ethanol; | 99.7% |
| With potassium carbonate In acetone Reflux; |
- 124-63-0
methanesulfonyl chloride
- 638-94-8
desonide
- 5541-39-9
11β-hydroxy-16α,17α-isopropylidenedioxy-21-mesyloxy-1,4-pregnadiene-3,20-dione
| Conditions | Yield |
|---|---|
| With pyridine at 0℃; | 99% |
Desonide Specification
1. Introduction of Desonide
Desonide is one kind of white needle crystal. This chemical belongs to the Product Categories which include Chiral Reagents; Intermediates & Fine Chemicals; Pharmaceuticals; Steroids. Desonide is mainly used to treat atopic dermatitis ,seborrheic dermatitis, and contact dermatitis in both adults and children , it is available as a cream, ointment, lotio.
2. Properties of Desonide
Desonide has the following prperty datas: (1)Freely Rotating Bonds: 4; (2)Polar Surface Area: 71.06?2; (3)Index of Refraction: 1.598; (4)Molar Refractivity: 109.26 cm3; (5)Molar Volume: 320.1 cm3; (6)Surface Tension: 55.9 dyne/cm; (7)Density: 1.3 g/cm3; (8)Flash Point: 196.9 °C; (9)Enthalpy of Vaporization: 99.64 kJ/mol; (10)Boiling Point: 580.1 °C at 760 mmHg; (11)Vapour Pressure: 7.16E-16 mmHg at 25°C.
3. Structure Descriptors of Desonide
You could convert the following datas into the molecular structure:
(1).InChI:InChI=1/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15?,16-,17?,19+,20+,22?,23?,24+/m0/s1
(2).Smiles:O1C(C)(C)O[C@@H]2C[C@@H]3[C@@](C[C@@H](O)[C@H]4[C@@H]3CCC=3[C@@]4(C=CC(C3)=O)C)(C)[C@]12C(=O)CO
4. Toxicity of Desonide
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | oral | 3710mg/kg (3710mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 111, 1970. | |
| rat | LD50 | subcutaneous | 93mg/kg (93mg/kg) | Toxicology and Applied Pharmacology. Vol. 20, Pg. 522, 1971. |
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