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Dextran

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Name

Dextran

EINECS 232-677-5
CAS No. 9004-54-0 Density
Solubility Melting Point -114.22oC
Formula [C6H10O5]n Boiling Point -85.05oC at 760 mm Hg
Molecular Weight 504.43700 Flash Point
Transport Information Appearance white crystals or powder
Safety 24/25-37/39-36-26 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 9004-54-0 (Dextran) Hazard Symbols IrritantXi,HarmfulXn
Synonyms

T 40(polysaccharide);T 5 (polysaccharide);T 500;T 500 (carbohydrate);T 6;T 70;Low molecular dextran-L;Dextrans;Dextran 10;Dextran 1000;Dextran 110;T 70 (carbohydrate);a-Dextran;Dextran 15;Dextran 2000;Dextran 250;Dextran 40;Dextran 40000;Dextran 500;Dextran 70;Dextran 75;Dextran T 10;Dextran T100;Dextran T 2000;Dextran T 40;Dextran T 500;Dextran T 70;Dextranen;Dextraven;Eudextran;Gentran;Gentran 40;Infucoll;Intradex;LVD;Macrodex;Macrose;Oncovertin N;Onkotin;PL 1S;Plasmodex;Plavolex;Polyglusol;Rheomacrodex;Rheopolyglucin;Rheopolyglucine;Rheotran;Rondex;Rondex (polysaccharide);Serva G;T 110;T 110 (carbohydrate);T 150;T 20 (carbohydrate);T 250;T 250 (polysaccharide);T 4;T 4 (polysaccharide);T 40;

 

Dextran Consensus Reports

Reported in EPA TSCA Inventory.

Dextran Specification

The systematic name of Dextran 70 is Dextran. With the CAS registry number 9004-54-0, it is also named as Low molecular dextran-L. The product's categories are Dextrins, Sugar & Carbohydrates; Carbohydrates D-FAlphabetic; DA - DH Biochemicals and Reagents; Biostabilization Agents Carbohydrates; Biostabilization Agents Biochemicals and Reagents; Carbohydrates A to; Carbohydrates D-FBiochemicals and Reagents; DA - DH Polymer Standards; Alphabetic; D; Dextran etc., and the other registry numbers are 11104-36-2; 11121-03-2; 12626-85-6; 128635-03-0; 37224-17-2; 60454-72-0; 86280-85-5; 9013-80-3; 9044-66-0; 911319-01-2. Besides, it is white crystals or powder, which should be stored in closed, cool and dry place at 2-8 °C. It is stable, and incompatible with strong oxidizing agents. In addition, its molecular formula is [C6H10O5]n.

Preparation and Uses of Dextran 70: this chemical can be prepared by microbial fermentation of Leyconostoc meseteroides. What's more, this chemical is used as an antithrombotic (anti-platelet), to reduce blood viscosity, and as a volume expander in anemia. it is also used in some eye drops as a lubricant, and in certain intravenous fluids to solubilise other factors, e.g. iron. Furthermore, it is in bead form used to aid in bioreactor applications. And it can be used to protect metal nanoparticles from oxidation and improve biocompatibility as a stabilising coating. Additionally, it can be used for industrial cell culture to make microcarriers.

When you are using this chemical, please be cautious about it as the following: it is harmful by inhalation, in contact with skin and if swallowed. You should avoid contact with skin and eyes. It is also irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. And you should wear suitable protective clothing, gloves and eye/face protection.

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 unreported 13500mg/kg (13500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gematologiya i Transfuziologiya. Hematology and Transfusion Science. Vol. 31(10), Pg. 38, 1986.
mouse LD50 intravenous 12100mg/kg (12100mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
mouse LD50 oral > 12gm/kg (12000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
mouse LD50 subcutaneous 13900mg/kg (13900mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rabbit LD50 intravenous 17400mg/kg (17400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rabbit LD50 intravenous 208gm/kg (208000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 3, Pg. 201, 1975.
rat LD50 intravenous 6900mg/kg (6900mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rat LD50 oral > 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
rat LD50 subcutaneous 10700mg/kg (10700mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 6, Pg. 1023, 1972.
women TDLo intravenous 6mg/kg (6mg/kg) CARDIAC: OTHER CHANGES

VASCULAR: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
British Medical Journal. Vol. 2, Pg. 1502, 1976.

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