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| CAS No.: | 26016-99-9 |
|---|---|
| Name: | Disodium phosphonomycin |
| Molecular Structure: | |
|
|
|
| Formula: | C3H5Na2O4P |
| Molecular Weight: | 182.024 |
| Synonyms: | Disodium phosphonomycin;Disodium fosfomycin;FOM-Na;Fosfocin;Fosfomycindisodium salt;Fosmicin S;Levo-phosphonomycin disodium salt;NSC 136017;Sodium fosfomycin;Phosphonicacid, P-[(2R,3S)-3-methyl-2-oxiranyl]-, sodium salt (1:2);Fosfomycin Sodium; |
| EINECS: | 247-409-2 |
| Melting Point: | >300 °C |
| Boiling Point: | 342.7oC at 760 mmHg |
| Flash Point: | 161°C |
| Solubility: | water: 50 mg/mL, clear, colorless |
| Appearance: | white solid |
| Hazard Symbols: |
 F, C
|
| Risk Codes: | 11-34 |
| Safety: | 16-26-36/37/39-45 |
| PSA: | 85.53000 |
| LogP: | 0.78530 |
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- 852475-26-4MC1568
- 26016-99-9
phosphomycin disodium salt
| Conditions | Yield |
|---|---|
| With sodium hydroxide for 1h; | 90% |
- 172585-28-3
dibenzyl (1R,2S)-1,2-epoxypropylphosphonate
- 26016-99-9
phosphomycin disodium salt
| Conditions | Yield |
|---|---|
| With Dowex 50WX8 (Na form); hydrogen; cyclohexylamine; palladium on activated charcoal In methanol | 76% |
- 119007-50-0
(1-bromo-2-hydroxypropyl)phosphonic acid
- 26016-99-9
phosphomycin disodium salt
| Conditions | Yield |
|---|---|
| With sodium methylate In methanol | 1.91 g |
- 640716-21-8
(1R,2S)-1-chloro-2-hydroxypropanephosphonic acid
- 26016-99-9
phosphomycin disodium salt
| Conditions | Yield |
|---|---|
| With sodium hydroxide In methanol pH=9 - 10; |
- 26016-99-9
phosphomycin disodium salt
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water | |
| With sodium hydroxide In water | |
| With sodium hydroxide In water |
- 26016-99-9
phosphomycin disodium salt
- 108-91-8
cyclohexylamine
- 132125-61-2
((1R,2R)-1,2-Dihydroxy-propyl)-phosphonic acid; compound with cyclohexylamine
| Conditions | Yield |
|---|---|
| With sulfuric acid at 50℃; for 48h; | 60% |
- 26016-99-9
phosphomycin disodium salt
A
- 128708-51-0
(1S,2S)-(+)-(1-Amino-2-hydroxypropyl)phosphonsaeure
B
- 84601-12-7
(1R,2R)-(-)-(2-Amino-1-hydroxypropyl)phosphonsaeure
| Conditions | Yield |
|---|---|
| With ammonia at 60℃; | A 42% B 58% |
- 855392-18-6
2-amino-2-hydroxymethyl-propane-1,3-diol; hydrogenoxalate
- 26016-99-9
phosphomycin disodium salt
- 78964-85-9
fosfomycin trometamol
| Conditions | Yield |
|---|---|
| In methanol at 20 - 65℃; for 3 - 4h; |
- 753-73-1
dimethyltin dichloride
- 26016-99-9
phosphomycin disodium salt
| Conditions | Yield |
|---|---|
| In methanol 1:1 mixt. stirred for 24 h at 40°C; pptd. on cooling, septd., recrystd. (benzene/chloroform=1/1), dried overP4O10 (vac.), elem. anal.; |
- 1066-45-1
trimethyltin(IV)chloride
- 26016-99-9
phosphomycin disodium salt
| Conditions | Yield |
|---|---|
| In methanol stoich. mixt. stirred for 24 h at 40°C; pptd. on cooling, septd., recrystd. (benzene/chloroform=1/1), dried overP4O10 (vac.), elem. anal.; |
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Chemistry
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IUPAC Name: Disodium [(2R,3S)-3-methyloxiran-2-yl]-dioxido-oxo-λ5-phosphane
Molecular Weight: 182.022701 [g/mol]
Molecular Formula: C3H5Na2O4P
H-Bond Donor: 0
H-Bond Acceptor: 4
EINECS: 247-409-2
Product Categories: chiral; Antibiotic Explorer; Intermediates & Fine Chemicals; Pharmaceuticals; Peptide Synthesis / Antibiotics
Storage temp.: 2-8 °C
Solubility: H2O: 50 mg/mL, clear, colorless
Appearance: White Solid
Melting Point: >300 °C
Classification Code of Disodium phosphonomycin (CAS NO.26016-99-9): Drug / Therapeutic Agent; Mutation data; Reproductive Effect
Uses
Disodium phosphonomycin (CAS NO.26016-99-9) is used as an antibiotic.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 2625mg/kg (2625mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
| mouse | LD50 | intraperitoneal | 2175mg/kg (2175mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981. | |
| mouse | LD50 | intravenous | 1225mg/kg (1225mg/kg) | SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE BEHAVIORAL: IRRITABILITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
| mouse | LD50 | oral | 7300mg/kg (7300mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
| mouse | LD50 | subcutaneous | 5100mg/kg (5100mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981. | |
| rat | LD50 | intramuscular | 2460mg/kg (2460mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
| rat | LD50 | intraperitoneal | 2gm/kg (2000mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
| rat | LD50 | intravenous | 1560mg/kg (1560mg/kg) | SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
| rat | LD50 | oral | 4550mg/kg (4550mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: MUSCLE WEAKNESS | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
| rat | LD50 | subcutaneous | 4320mg/kg (4320mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. |
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intravenous and intramuscular routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of POx and Na2O.
Hazard Codes:
F,
C
Risk Statements: 11-34
11: Highly Flammable
34: Causes burns
Safety Statements: 16-26-36/37/39-45
16: Keep away from sources of ignition - No smoking
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37/39: Wear suitable protective clothing, gloves and eye/face protection
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
WGK Germany: 2
RTECS: SZ7902000
F: 10-21
F10: Keep under argon.
F21: Sensitive to humidity.
Specification
Disodium phosphonomycin (CAS NO.26016-99-9), its Synonyms are (1R,2S)(-)-(1,2-Epoxypropyl)phosphonic acid disodium salt ; (2R-cis)-(3-Methyloxiranyl)phosphonic acid disodium salt ; Disodium fosfomycin ; Fosfocina disodium salt ; Fosfomycin disodium ; Fosfomycin disodium salt ; Fosfomycin sodium ; Fosfomycin sodium salt ; Phosphonemycin ; Phosphonomycin disodium salt ; Phosphonomycin sodium ; Priomicina ; Sodium fosfomycin ; Veramina ; Disodium (1R,2S)-(1,2-epoxypropyl)phosphonate ; Phosphonic acid, (1,2-epoxypropyl)-, disodium salt (1R,2S) (-)- ; Phosphonic acid, (3-methyloxiranyl)-, disodium salt, (2R-cis)- (9CI) .