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Ethoxytrimethylsilane

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Name

Ethoxytrimethylsilane

EINECS 217-370-6
CAS No. 1825-62-3 Density 0.772 g/cm3
PSA 9.23000 LogP 1.85780
Solubility reacts with water Melting Point -83 °C
Formula C5H14OSi Boiling Point 75.5 °C at 760 mmHg
Molecular Weight 118.251 Flash Point -18 °C
Transport Information UN 1993 3/PG 2 Appearance clear colorless liquid
Safety 16-26-9-37/39-33 Risk Codes 11-22-36/37/38
Molecular Structure Molecular Structure of 1825-62-3 (Ethoxytrimethylsilane) Hazard Symbols FlammableF, HarmfulXn, IrritantXi
Synonyms

Ethyl trimethylsilyl ether;Trimethylsilicon ethoxide;Trimethylsilyl ethoxide;Trimethylsilyl ethyl ether;LS 875;NSC 43345;Silane M 3-ethoxy;Trimethylethoxysilane;

Article Data 146

Ethoxytrimethylsilane Synthetic route

64-17-5

ethanol

Nafion-TMS

Nafion-TMS

1825-62-3

ethyl trimethylsilyl ether

Conditions
ConditionsYield
With triethylamine In dichloromethane at 27℃; for 3h;100%
64-17-5

ethanol

114518-51-3

N,N'-bis<(trimethylsiloxy)carbonyl>-N,N'-bis(trimethylsilyl)hydrazine

1825-62-3

ethyl trimethylsilyl ether

Conditions
ConditionsYield
97.5%
64-17-5

ethanol

999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

1825-62-3

ethyl trimethylsilyl ether

Conditions
ConditionsYield
With tetrabutylammonium phthalimide-N-oxyl In ethyl acetate for 1h; Reflux;96%
With [nano-MCM-41(at)(CH2)3-1-methylimidazole]Br3 In dichloromethane at 20℃; for 0.416667h;90%
122-51-0

orthoformic acid triethyl ester

A

74-96-4

ethyl bromide

B

1825-62-3

ethyl trimethylsilyl ether

C

109-94-4

formic acid ethyl ester

Conditions
ConditionsYield
With chloro-trimethyl-silane; sodium bromide for 2h; Product distribution; Heating; Me3SiBr generated in situ;A n/a
B n/a
C 92%
64-17-5

ethanol

17881-28-6

N,N'-trimethylsilyl(phenyl)diazene

A

1825-62-3

ethyl trimethylsilyl ether

B

1227476-15-4

Azobenzene

C

71-43-2

benzene

Conditions
ConditionsYield
for 0.5h; Ambient temperature;A 92%
B 0.01 mmol
C 66%
43112-38-5

3-(trimethylsilyl)-2-oxazolidinone

64-17-5

ethanol

1825-62-3

ethyl trimethylsilyl ether

Conditions
ConditionsYield
chloro-trimethyl-silane at 20℃; for 0.0166667h;90%
5573-62-6

(ethylthio)trimethylsilane

122-51-0

orthoformic acid triethyl ester

A

1825-62-3

ethyl trimethylsilyl ether

B

6267-24-9

tris(ethylsulfanyl)methane

Conditions
ConditionsYield
With zinc(II) chloride In toluene at 0℃; for 5h;A 85%
B 90%
122-51-0

orthoformic acid triethyl ester

153080-50-3

C7H19PS4Si

A

1825-62-3

ethyl trimethylsilyl ether

B

S,S'-diethyl-S''-bis(1-ethoxy)methyl tetrathiophosphate

Conditions
ConditionsYield
at 20℃; for 2h;A 90%
B 69%
64-17-5

ethanol

56002-69-8

trimethyl-(1H,1H,3H-tetrafluoropropoxy)silane

1825-62-3

ethyl trimethylsilyl ether

Conditions
ConditionsYield
at 20℃; for 1h;88.9%
78-08-0

Triethoxyvinylsilane

77214-46-1

N-<(β-trimethylsiloxy)ethyl>formamide

A

1825-62-3

ethyl trimethylsilyl ether

B

N-<2-(diethoxyvinylsiloxy)ethyl>formamide

Conditions
ConditionsYield
With aluminum isopropoxide for 0.166667h; Yields of byproduct given;A n/a
B 86%

Ethoxytrimethylsilane Consensus Reports

Reported in EPA TSCA Inventory.

Ethoxytrimethylsilane Specification

The IUPAC name of this chemical is ethoxy(trimethyl)silane. With the CAS registry number 1825-62-3 and EINECS 217-370-6, it is also named as Silane, ethoxytrimethyl-. The product's categories are Monoalkoxysilanes; Si (Classes of Silicon Compounds); Si-O Compounds. It is clear colorless liquid which reacts with water. When heated to decomposition it emits acrid smoke and irritating fumes. Additioanlly, this chemical should be sealed in the container and stored in the cool, well-ventilated and dry place. People should ensure that the workplace has well-ventilated equipment.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.15; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.15; (4)ACD/LogD (pH 7.4): 2.15; (5)ACD/BCF (pH 5.5): 25.37; (6)ACD/BCF (pH 7.4): 25.37; (7)ACD/KOC (pH 5.5): 352.2; (8)ACD/KOC (pH 7.4): 352.2; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 2; (12)Polar Surface Area: 9.23 Å2; (13)Index of Refraction: 1.382; (14)Molar Refractivity: 35.67 cm3; (15)Molar Volume: 153.1 cm3; (16)Polarizability: 14.14×10-24 cm3; (17)Surface Tension: 16.7 dyne/cm; (18)Enthalpy of Vaporization: 30.35 kJ/mol; (19)Vapour Pressure: 115 mmHg at 25°C; (20)Rotatable Bond Count: 2; (21)Exact Mass: 118.081392; (22)MonoIsotopic Mass: 118.081392; (23)Topological Polar Surface Area: 9.2; (24)Heavy Atom Count: 7; (25)Complexity: 46.5.

Preparation of Ethoxytrimethylsilane: It can be obtained by chloro-trimethyl-silane and ethanol. This reaction needs reagent urea at temperature of 20 °C. The reaction time is 4 hours. The yield is 80.2%.

Ethoxytrimethylsilane can be obtained by chloro-trimethyl-silane and ethanol

Uses of Ethoxytrimethylsilane: It is used in the synthesis of organic silicon compounds. And it is also used as water repellent. Besides, it can react with benzene-1,2,4,5-tetracarbonitrile to get 5-Methyl-1,2,4-benzenetricarbonitrile. This reaction needs solvent acetonitrile by irradiation. The reaction time is 2 hours. The yield is 85%.

Ethoxytrimethylsilane can react with benzene-1,2,4,5-tetracarbonitrile to get 5-Methyl-1,2,4-benzenetricarbonitrile

When you are using this chemical, please be cautious about it as the following:
It is not only harmful if swallowed, but also irritating to eyes, respiratory system and skin. And it is highly flammable, so people should keep away from sources of ignition. In case of contacting with eyes, rinse immediately with plenty of water and seek medical advice. After using it, take precautionary measures against static discharges. If you want to contact this product, you must wear suitable gloves and eye/face protection. 

People can use the following data to convert to the molecule structure. 
1. SMILES:O(CC)[Si](C)(C)C
2. InChI:InChI=1/C5H14OSi/c1-5-6-7(2,3)4/h5H2,1-4H3 
3. InChIKey:RSIHJDGMBDPTIM-UHFFFAOYAV

The following are the toxicity data which has been tested.

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LCLo inhalation 4000ppm/8H (4000ppm) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 332, 1948.
rat LDLo oral 1400mg/kg (1400mg/kg)   Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 332, 1948.

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