- Fexofenadine
- Fexofenadine hydrochloride
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Cas Database |
| Name |
Fexofenadine |
EINECS | 801-893-7 |
| CAS No. | 83799-24-0 | Density | 1.171 g/cm3 |
| PSA | 81.00000 | LogP | 5.44840 |
| Solubility | N/A | Melting Point |
218-220 °C |
| Formula | C32H39NO4 | Boiling Point | 697.3 °C at 760 mmHg |
| Molecular Weight | 501.666 | Flash Point | 375.5 °C |
| Transport Information | N/A | Appearance | white powder |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
4-[4-[4-(Hydroxydiphenylmethyl)-1-piperidinyl]-1-hydroxybutyl]-a,a-dimethylphenylacetic acid;Carboxyterfenadine;MDL 16455;Terfenadine acid metabolite;Terfenadine carboxylate;Benzeneacetic acid,4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]-a,a-dimethyl-; |
Article Data | 47 |
Fexofenadine Chemical Properties
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IUPAC Name: 2-[4-[1-hydroxy-4-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]butyl]phenyl]-2-methylpropanoic acid
Molecular Formula: C32H39NO4
Molecular Weight: 501.66
Classification Code: Anti-Allergic Agents; Histamine Agents; Histamine Antagonists; Histamine H1 Antagonists, Non-Sedating; Histamine H1 antagonists; Neurotransmitter Agents
Melting Point: 218-220 °C
Index of Refraction: 1.596
Molar Refractivity: 145.86 cm3
Molar Volume: 428.1 cm3
Surface Tension: 52.4 dyne/cm
Density: 1.171 g/cm3
Flash Point: 375.5 °C
Enthalpy of Vaporization: 107.22 kJ/mol
Boiling Point: 697.3 °C at 760 mmHg
Vapour Pressure of Fexofenadine (CAS NO.83799-24-0): 2.08E-20 mmHg at 25 °C
Fexofenadine Uses
Fexofenadine (CAS NO.83799-24-0) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine (brand names include Triludan and Seldane), an antihistamine with potentially serious contraindications. Fexofenadine, like other second and third-generation antihistamines, does not readily cross the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists. It works by being an antagonist to the H1 receptor.
Fexofenadine Production
Fexofenadine may be synthesized as shown from piperidine-4-carboxylate ester and 4-bromophenylacetonitrile.(1).jpg)
Fexofenadine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 144mg/kg/9W-I (144mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | Lancet. Vol. 353, Pg. 980, 1999. |
Fexofenadine Specification
Fexofenadine (CAS NO.83799-24-0), its Synonyms are 4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)-1-piperidinyl)butyl)-alpha,alpha-dimethylbenzeneacetic acid ; Carboxyterfenadine ; Terfenadine acid metabolite ; Terfenadine carboxylate ; Terfenadine-COOH . It is white powder.
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