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Cas Database

Name	Flufenamic acid	EINECS	208-494-1
CAS No.	530-78-9	Density	1.396 g/cm³
PSA	49.33000	LogP	4.22020
Solubility	0.0265 g/L (37 ºC)	Melting Point	132-135 °C(lit.)
Formula	C₁₄H₁₀F₃NO₂	Boiling Point	373.903 °C at 760 mmHg
Molecular Weight	281.234	Flash Point	179.93 °C
Transport Information	UN 2811 6.1/PG 3	Appearance	pale-yellow solid
Safety	26	Risk Codes	22-36/38
Molecular Structure		Hazard Symbols	Xn
Synonyms	Anthranilicacid, N-(a,a,a-trifluoro-m-tolyl)- (6CI,8CI);2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid;3'-Trifluoromethyldiphenylamine-2-carboxylic acid;Achless;Arlef;Fullsafe;Meralen;Movilizin;N-(a,a,a-Trifluoro-m-tolyl)anthranilic acid;N-[3-(Trifluoromethyl)phenyl]anthranilic acid;Pinox;	Article Data	29

Flufenamic acid Synthetic route

: 2-(3-trifluoromethyl-phenylamino)-benzoic acid (diethylcarbamoylmethyl-methyl-carbamoyloxy)-methyl ester

A: 44897-15-6
sarcosine diethylamide

B: 530-78-9
flufenamic acid

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A n/a B 100%

: 2-(3-trifluoromethyl-phenylamino)-benzoic acid diethylcarbamoylmethylcarbamoyloxymethyl ester

A: 34105-57-2
2-amino-N,N-diethylacetamide

B: 530-78-9
flufenamic acid

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A n/a B 100%

: 2-diethylcarbamoyl-pyrrolidine-1-carboxylic acid 2-(3-trifluoromethyl-phenylamino)-benzoyloxymethyl ester

A: 530-78-9
flufenamic acid

B: 41721-01-1
(2S)-N',N'-diethylpyrrolidinecarboxamide

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A 100% B n/a

: 2-(3-trifluoromethyl-phenylamino)-benzoic acid 1-diethylcarbamoyl-2-phenyl-ethylcarbamoyloxymethyl ester

A: 530-78-9
flufenamic acid

B: 40847-09-4
N-(phenylalanyl)-N,N-diethylamine

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A 100% B n/a

: 2-(3-trifluoromethyl-phenylamino)-benzoic acid 1-benzyl-2-morpholin-4-yl-2-oxo-ethylcarbamoyloxymethyl ester

A: 530-78-9
flufenamic acid

B: 141834-13-1
N-(phenylalanyl)morpholine

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A 100% B n/a

: 2-(3-trifluoromethyl-phenylamino)-benzoic acid 1-benzyl-2-oxo-2-piperidin-1-yl-ethylcarbamoyloxymethyl ester

A: 530-78-9
flufenamic acid

B: 102292-89-7
(2S)-2-amino-3-phenyl-1-(piperidin-1-yl)propan-1-one

Conditions

Conditions	Yield
With human plasma In phosphate buffer at 37℃; pH=7.4;	A 100% B n/a

: 13481-62-4
2-((3-(trifluoromethyl)phenyl)amino)benzonitrile

: 530-78-9
flufenamic acid

Conditions

Conditions	Yield
With potassium hydroxide In ethanol; water at 95℃; for 20h;	98%

: 98-16-8
3-trifluoromethylaniline

: 118-91-2
ortho-chlorobenzoic acid

: 530-78-9
flufenamic acid

Conditions

Conditions	Yield
With potassium carbonate; copper In N,N-dimethyl-formamide for 2h; Heating;	60%
With copper(l) iodide; copper; potassium carbonate In N,N-dimethyl-formamide for 0.333333h; Heating; ultrasonic irradiation;	24%
(i) aq. KOH, (ii) /BRN= 387672/, Cu; Multistep reaction;

: 2765-91-5
2-[[3-(trifluoromethyl)phenyl]amino]benzoic acid,methyl ester

: 530-78-9
flufenamic acid

Conditions

Conditions	Yield
With water; potassium hydroxide In ethanol at 100℃; Inert atmosphere;	55%
Stage #1: 2-[[3-(trifluoromethyl)phenyl]amino]benzoic acid,methyl ester With potassium hydroxide In ethanol; water at 20 - 100℃; Inert atmosphere; Stage #2: With hydrogenchloride In water at 0℃; pH=2; Inert atmosphere;	55%
With water; potassium hydroxide In ethanol at 100℃;	55%
With hydrazine hydrate In methanol

: 88-67-5
2-Iodobenzoic acid

: 98-16-8
3-trifluoromethylaniline

: 530-78-9
flufenamic acid

Conditions

Conditions	Yield
With water; copper; potassium carbonate
With 4-methyl-morpholine; copper(I) oxide In 1,4-dioxane at 100℃; for 3h; Ullmann Condensation; Inert atmosphere;

Flufenamic acid Chemical Properties

Chemical Name: Flufenamic acid
IUPAC NAME: 2-[3-(Trifluoromethyl)anilino]benzoic acid
CAS No.: 530-78-9
EINECS: 208-494-1
RTECS: CB4375000
RTECS Class: Drug ; Mutagen ; Reproductive Effector ; Human Data
Molecular Formula: C₁₄H₁₀F₃NO₂
Molecular Weight: 281.23 g/mol
Melting Point: 132-135 °C(lit.)
Density: 1.395 g/cm³
Flash Point: 179.9 °C
Boiling Point: 373.9 °C at 760 mmHg
Following is the structure of N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9):

Product Categories about N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9) are Active Pharmaceutical Ingredients ; Aromatics ; Intermediates & Fine Chemicals ; Pharmaceuticals ; API's
The chemical synonymous of N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9) are Inf1837 ; Lanceat ; Meralen ; N-((M-Trifluoromethyl)phenyl)-2-Aminobenzoic acid ; N-(α,α,α-trifluoro-m-tolyl)anthranilate ; N-(α,α,α-trifluoro-m-tolyl)-anthranilicaci ; N-(M-Trifluoromethylphenyl)-2-aminobenzoicacid ; Nichisedan

Flufenamic acid Uses

N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9) is used as an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.

Flufenamic acid Toxicity Data With Reference

1.	dni-hmn-unr 504 mg/kg/8W	STBIBN Studia Biophysica. 50 (1975),172.
2.	orl-wmn TDLo:2160 mg/kg/26W-I:GIT	PGMJAO Postgraduate Medical Journal. 62 (1986),773.
3.	orl-rat LD50:249 mg/kg	AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 221 (1976),132.
4.	ipr-rat LD50:185 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 16 (1978),1011.
5.	ivn-rat LD50:98 mg/kg	CMROCX Current Medical Research and Opinion. 4 (1976),17.
6.	orl-mus LD50:490 mg/kg	OYYAA2 Oyo Yakuri. Pharmacometrics. 16 (1978),1011.
7.	ipr-mus LD50:150 mg/kg	NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 .
8.	ivn-mus LD50:158 mg/kg	YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. 89 (1969),1392.

Flufenamic acid Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. Human systemic effects: hypermotility, diarrhea. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F⁻ and NO_x. Used as an anti-inflammatory agent. See also FLUORIDES.
Hazard Codes:
Xi: Irritant
Risk Statements about N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9):
R21/22 Harmful in contact with skin and if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Attentions:
1. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation.

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