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CAS No.: | 530-78-9 |
---|---|
Name: | Flufenamic acid |
Article Data: | 29 |
Molecular Structure: | |
Formula: | C14H10F3NO2 |
Molecular Weight: | 281.234 |
Synonyms: | Anthranilicacid, N-(a,a,a-trifluoro-m-tolyl)- (6CI,8CI);2-[[3-(Trifluoromethyl)phenyl]amino]benzoic acid;3'-Trifluoromethyldiphenylamine-2-carboxylic acid;Achless;Arlef;Fullsafe;Meralen;Movilizin;N-(a,a,a-Trifluoro-m-tolyl)anthranilic acid;N-[3-(Trifluoromethyl)phenyl]anthranilic acid;Pinox; |
EINECS: | 208-494-1 |
Density: | 1.396 g/cm3 |
Melting Point: | 132-135 °C(lit.) |
Boiling Point: | 373.903 °C at 760 mmHg |
Flash Point: | 179.93 °C |
Solubility: | 0.0265 g/L (37 ºC) |
Appearance: | pale-yellow solid |
Hazard Symbols: | Xn |
Risk Codes: | 22-36/38 |
Safety: | 26 |
Transport Information: | UN 2811 6.1/PG 3 |
PSA: | 49.33000 |
LogP: | 4.22020 |
Conditions | Yield |
---|---|
With human plasma In phosphate buffer at 37℃; pH=7.4; | A n/a B 100% |
A
2-amino-N,N-diethylacetamide
B
flufenamic acid
Conditions | Yield |
---|---|
With human plasma In phosphate buffer at 37℃; pH=7.4; | A n/a B 100% |
Conditions | Yield |
---|---|
With human plasma In phosphate buffer at 37℃; pH=7.4; | A 100% B n/a |
Conditions | Yield |
---|---|
With human plasma In phosphate buffer at 37℃; pH=7.4; | A 100% B n/a |
Conditions | Yield |
---|---|
With human plasma In phosphate buffer at 37℃; pH=7.4; | A 100% B n/a |
Conditions | Yield |
---|---|
With human plasma In phosphate buffer at 37℃; pH=7.4; | A 100% B n/a |
2-((3-(trifluoromethyl)phenyl)amino)benzonitrile
flufenamic acid
Conditions | Yield |
---|---|
With potassium hydroxide In ethanol; water at 95℃; for 20h; | 98% |
Conditions | Yield |
---|---|
With potassium carbonate; copper In N,N-dimethyl-formamide for 2h; Heating; | 60% |
With copper(l) iodide; copper; potassium carbonate In N,N-dimethyl-formamide for 0.333333h; Heating; ultrasonic irradiation; | 24% |
(i) aq. KOH, (ii) /BRN= 387672/, Cu; Multistep reaction; |
Conditions | Yield |
---|---|
With water; potassium hydroxide In ethanol at 100℃; Inert atmosphere; | 55% |
Stage #1: 2-[[3-(trifluoromethyl)phenyl]amino]benzoic acid,methyl ester With potassium hydroxide In ethanol; water at 20 - 100℃; Inert atmosphere; Stage #2: With hydrogenchloride In water at 0℃; pH=2; Inert atmosphere; | 55% |
With water; potassium hydroxide In ethanol at 100℃; | 55% |
With hydrazine hydrate In methanol |
Conditions | Yield |
---|---|
With water; copper; potassium carbonate | |
With 4-methyl-morpholine; copper(I) oxide In 1,4-dioxane at 100℃; for 3h; Ullmann Condensation; Inert atmosphere; |
Chemical Name: Flufenamic acid
IUPAC NAME: 2-[3-(Trifluoromethyl)anilino]benzoic acid
CAS No.: 530-78-9
EINECS: 208-494-1
RTECS: CB4375000
RTECS Class: Drug ; Mutagen ; Reproductive Effector ; Human Data
Molecular Formula: C14H10F3NO2
Molecular Weight: 281.23 g/mol
Melting Point: 132-135 °C(lit.)
Density: 1.395 g/cm3
Flash Point: 179.9 °C
Boiling Point: 373.9 °C at 760 mmHg
Following is the structure of N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9):
Product Categories about N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9) are Active Pharmaceutical Ingredients ; Aromatics ; Intermediates & Fine Chemicals ; Pharmaceuticals ; API's
The chemical synonymous of N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9) are Inf1837 ; Lanceat ; Meralen ; N-((M-Trifluoromethyl)phenyl)-2-Aminobenzoic acid ; N-(α,α,α-trifluoro-m-tolyl)anthranilate ; N-(α,α,α-trifluoro-m-tolyl)-anthranilicaci ; N-(M-Trifluoromethylphenyl)-2-aminobenzoicacid ; Nichisedan
N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9) is used as an anthranilic acid derivative with analgesic, anti-inflammatory, and antipyretic properties.
1. | dni-hmn-unr 504 mg/kg/8W | STBIBN Studia Biophysica. 50 (1975),172. | ||
2. | orl-wmn TDLo:2160 mg/kg/26W-I:GIT | PGMJAO Postgraduate Medical Journal. 62 (1986),773. | ||
3. | orl-rat LD50:249 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 221 (1976),132. | ||
4. | ipr-rat LD50:185 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 16 (1978),1011. | ||
5. | ivn-rat LD50:98 mg/kg | CMROCX Current Medical Research and Opinion. 4 (1976),17. | ||
6. | orl-mus LD50:490 mg/kg | OYYAA2 Oyo Yakuri. Pharmacometrics. 16 (1978),1011. | ||
7. | ipr-mus LD50:150 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD691-490 . | ||
8. | ivn-mus LD50:158 mg/kg | YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. 89 (1969),1392. |
Poison by ingestion, intravenous, and intraperitoneal routes. Experimental reproductive effects. Human systemic effects: hypermotility, diarrhea. Human mutation data reported. When heated to decomposition it emits very toxic fumes of F− and NOx. Used as an anti-inflammatory agent. See also FLUORIDES.
Hazard Codes:
Xi: Irritant
Risk Statements about N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9):
R21/22 Harmful in contact with skin and if swallowed.
R36/37/38 Irritating to eyes, respiratory system and skin.
Safety Statements about N-(α,α,α-TRIFLUORO-m-TOLYL)ANTHRANILIC ACID (530-78-9):
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
Attentions:
1. Storage: Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.
2. Handling: Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation. Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation.