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Fluvoxamine maleate

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Name

Fluvoxamine maleate

EINECS 228-994-3
CAS No. 61718-82-9 Density N/A
PSA 131.44000 LogP 3.61360
Solubility Soluble in water Melting Point 120-121.5 °C
Formula C15H21F3N2O2.C4H4O4 Boiling Point 370.6 °C at 760 mmHg
Molecular Weight 434.413 Flash Point 177.9 °C
Transport Information N/A Appearance white crystalline powder
Safety 36-36/37/39-27-26 Risk Codes 22-36/37/38
Molecular Structure Molecular Structure of 61718-82-9 (Fluvoxamine maleate) Hazard Symbols HarmfulXn; IrritantXi
Synonyms

2-{[(E)-{5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino]oxy}ethanamine (2Z)-but-2-enedioate (1:1);acide (2Z)-but-2-ènedio?que - 2-[({(1E)-5-méthoxy-1-[4-(trifluorométhyl)phényl]pentylidène}amino)oxy]éthanamine (1:1);MK 264 {Maleate};

Article Data 2

Fluvoxamine maleate Specification

The Fluvoxamine maleate, with the CAS registry number 61718-82-9 and EINECS registry number 228-994-3, is also called 1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)-, (2Z)-2-butenedioate (1:1). It is a kind of crystalline solid, and belongs to the following product categories: Amines; Aromatics; Intermediates & Fine Chemicals; Pharmaceuticals; Serotonin receptor. The molecular formula of the chemical is C15H21F3N2O2.C4H4O4, and it should be stored at 2-8°C. What's more, it is a selective serotonin reuptake inhibitor (SSRI) used as an anti-depressant.

The physical properties of Fluvoxamine maleate are as following: (1)ACD/LogP: 3.11; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 0; (4)ACD/LogD (pH 7.4): 1; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 2; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 13; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 10; (12)Polar Surface Area: 34.06 Å2; (13)Flash Point: 177.9 °C; (14)Enthalpy of Vaporization: 61.75 kJ/mol; (15)Boiling Point: 370.6 °C at 760 mmHg; (16)Vapour Pressure: 1.1E-05 mmHg at 25°C.

You should be cautious while dealing with this chemical. It irritates eyes, respiratory system and skin, and it is also harmful if swallowed. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Take off immediately all contaminated clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: FC(F)(F)c1ccc(\C(=N\OCCN)CCCCOC)cc1.O=C(O)\C=C/C(=O)O
(2)InChI: InChI=1/C15H21F3N2O2.C4H4O4/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18;5-3(6)1-2-4(7)8/h5-8H,2-4,9-11,19H2,1H3;1-2H,(H,5,6)(H,7,8)/b20-14+;2-1-
(3)InChIKey: LFMYNZPAVPMEGP-PIDGMYBPBW

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 464mg/kg (464mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 395, 2000.
human TDLo oral 64286ug/kg (64.286mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Journal of International Medical Research. Vol. 21, Pg. 197, 1993.
man TDLo oral 175mg/kg/13W- (175mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 38, Pg. 942, 1999.
mouse LD50 oral 1100mg/kg (1100mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Journal of International Medical Research. Vol. 21, Pg. 197, 1993.
rat LDLo oral 1500mg/kg (1500mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 4149, 1994.
women TDLo oral 10mg/kg (10mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES
Medical Toxicology. Vol. 1, Pg. 411, 1986.
 

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