New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90

Article abstract of DOI:10.1021/jm0707774

Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins involved in cell proliferation and survival, angiogenesis, and metastasis. Investigation of novobiocin analogues lacking the noviose moiety as novel inhibitors of hsp