Regio- and Stereoselective Control in the Addition of Grignard Reagents to the Pyridine Ring System

DOI: 10.1021/jo00356a016

Source and publish data:

Journal of Organic Chemistry p. 838 - 841 (1986)

Update date:2022-07-29

Topics:

Authors:

Schulz, Arthur G.

Flood, Lawrence

Springer, James P.

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Article abstract of DOI:10.1021/jo00356a016

The N-methyl and N-benzyl salts of nicotinic acid derivative 7a (e.g., 8 and 9) undergo regio- and stereoselective addition with Grignard reagents to give 10 as the major reaction product.Selectivities as high as >99:1 are observed.Addition of alkyllithiu

Full text of DOI:10.1021/jo00356a016

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