Journal of Organic Chemistry p. 838 - 841 (1986)
Update date:2022-07-29
Topics:
Schulz, Arthur G.
Flood, Lawrence
Springer, James P.
The N-methyl and N-benzyl salts of nicotinic acid derivative 7a (e.g., 8 and 9) undergo regio- and stereoselective addition with Grignard reagents to give 10 as the major reaction product.Selectivities as high as >99:1 are observed.Addition of alkyllithiu
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