Approach to the Total Synthesis of Chlorothricolide: Synthesis of (+/-)-19,20-Dihydro-24-O-methylchlorothricolide, Methyl ester, Ethyl Carbonate

DOI: 10.1021/jo00355a013

Source and publish data:

Journal of Organic Chemistry p. 635 - 648 (1986)

Update date:2022-09-26

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Authors:

Ireland, Robert E.

Varney, Michael D.

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Article abstract of DOI:10.1021/jo00355a013

An approach to the total synthesis of the macrolide antibiotic aglycone chlorothricolide (1b) is presented.Herein is described the synthesis of the advanced intermediate (+/-)-19,20-dihydro-24-O-methylchlorothricolide, methyl ester, ethyl carbonate (34) f

Full text of DOI:10.1021/jo00355a013

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