Communication
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In summary, we have developed a novel palladium-catalyzed
Ugi-type reaction for the synthesis of N-acyl anthranilamides
from isocyanides, 2-iodoanilines and carboxylic acids. This
transition-metal-catalyzed approach features advantages such
as readily available starting materials, high bond-forming
efficiency, and broad functional group compatibility, and is
successfully applied in the late-stage functionalization of com-
mercial drugs. Further studies for extending the application of
this method and biological evaluation of N-acyl anthranilamide
products are in progress.
T. Y. thanks Shaanxi University of Science and Technology
(BJ15-33) for financial support. X. Q. is grateful for the support
of the National Natural Science Foundation of China
(82073726), and the Key Research and Development Program
of Shaanxi Province (2020SF-226).
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Conflicts of interest
There are no conflicts to declare.
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