TOTAL SYNTHESIS OF VERTICILLENE, THE PUTATIVE BIOGENETIC PRECURSOR OF THE TAXANE ALKALOIDS.

Article abstract of DOI:10.1016/S0040-4039(00)98306-0

Intramolecular reductive coupling of the bis-aldehyde(14) in the presence of Ti(O), followed by 1,4-reduction of the resulting tetraene(16) using sodium in ammonia, provides a facile synthesis of E,E-verticillene(2), the putative biogenetic precursor of t