Novel synthesis of 2-aminopentanedinitriles from 2-(bromomethyl)aziridines and their transformation into 2-imino-5-methoxypyrrolidines and 5-methoxypyrrolidin-2-ones

DOI: 10.1016/j.tet.2007.03.116

Source and publish data:

Tetrahedron p. 1064 - 1070 (2008)

Update date:2022-09-26

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Authors:

D'hooghe, Matthias

Van Nieuwenhove, Andries

Van Brabandt, Willem

Rottiers, Mario

De Kimpe, Norbert

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Article abstract of DOI:10.1016/j.tet.2007.03.116

1-Arylmethyl-2-(bromomethyl)aziridines were transformed into 2-[N-(arylmethyl)amino]pentanedinitriles upon treatment with an excess of potassium cyanide in DMSO through an unprecedented and peculiar reaction mechanism, involving base-induced ring opening

Full text of DOI:10.1016/j.tet.2007.03.116

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