Synthesis and biological activity of a-hydroxyphosphonates

Article abstract of DOI:10.1080/10426500701793279

Ten α-hydroxyphosphates were synthesized and the preliminary bioessay indicated that these compounds exhibited certain herbicidal activities. Copyright Taylor & Francis Group, LLC.

Full text of DOI:10.1080/10426500701793279

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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Synthesis and
Biological Activity of A-
Hydroxyphosphonates
Na Zuo a & Hong-wu He a
a Key Laboratory of Pesticide and Chemical Biology
of Ministry of Education, College of Chemistry
Central China Normal University, Wuhan, P. R. China
Published online: 21 Jun 2008.
To cite this article: Na Zuo & Hong-wu He (2008) Synthesis and Biological Activity of
A-Hydroxyphosphonates, Phosphorus, Sulfur, and Silicon and the Related Elements,
183:2-3, 621-622, DOI: 10.1080/10426500701793279
To link to this article: http://dx.doi.org/10.1080/10426500701793279
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Phosphorus, Sulfur, and Silicon, 183:621–622, 2008
Copyright © Taylor & Francis Group, LLC
ISSN: 1042-6507 print / 1563-5325 online
DOI: 10.1080/10426500701793279
Synthesis and Biological Activity of
A-Hydroxyphosphonates
Na Zuo and Hong-wu He
Key Laboratory of Pesticide and Chemical Biology of Ministry of
Education, College of Chemistry Central China Normal University,
Wuhan, P. R. China
Ten α-hydroxyphosphates were synthesized and the preliminary bioessay indicated
that these compounds exhibited certain herbicidal activities.
Keywords α-hydroxyphosphonates; synthesis; herbicidal activity
Some hydroxyphosphonates and its derivatives have shown good bi-
ological and pharmaceutical activities. In continuation of our work, a
number of α-hydroxyphosphnates have been synthesized.1 and 2 was
prepared according to the literature procedures. 2 was reacted with var-
ious aldehydes by the Pudovik reaction to form the title compounds 3
in good yields (80–90%). Triethylamine was used as catalyst. The best
reaction time was 2–3 h and the temperature was 25◦C. All 10 com-
pounds were confirmed by 1H NMR, IR and element analysis, and one
was examined by the single crystal X-ray diffraction. The results of pre-
liminary bioassay indicated that the title compounds exhibited certain
herbicidal activities. Some α-hydroxyphosphonates and its derivatives
have shown good biological and pharmaceutical activities.1−3 1 and 2
was prepared according to the literature procedures.4,5
SCHEME 1
Financial support was provided by the National Basic Research Program of China
(2003CB114400) and NNSF of China (20372023).
Address correspondence to Hongwu He, Key Laboratory of Pesticide and Chemical
Biology of Ministry of Education, College of Chemistry Central China Normal University,
Wuhan 430079, P. R. China. E-mail: he1208@mail.ccnu.edu.cn
621

622
N. Zuo and H.-W. He
R=alkyl, Ph, substituted Ph, Furfuryl
SCHEME 2
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