Journal of Organic Chemistry p. 1120 - 1123 (1986)
Update date:2022-08-02
Topics:
Liu, Jia-Ming
Young, Jenn-Jong
Li, Yu-Jang
Sha, Chin-Kang
A general synthesis of substituted 1,2-dihydroisoquinolines based on intramolecular 1,3-dipolar cycloaddition of alkyl azides and olefins is described.Reaction of bromide 4 with sodium azide afforded azide 5, which underwent 1,3-dipolar cycloaddition intramolecularly to give triazoline 6 .Rearrangement of triazoline 6 on silica gel gave diazo compound 7.Treatment of 7 with rhodium acetate afforded substituted 1,2-dihydroisoquinoline 9 in good overall yield.
View Morewebsite:http://www.amadischem.com
Contact:86-571-89925085
Address:Watts Cosine.No.166.Xiangmao Road.
zhenjiang runjing high purity chemical co ltd
Contact:+86-511-83361155
Address:No.8.haixi road,international chemical park
Contact:86-21-31200601
Address:Room1618,FangzhengDaSha,No.1122 Xinjinqiao Road,Pudong New District,Shanghai ,China
JIAXING SUNS INTERNATIONAL TRADE CO LTD
Contact:18367306858
Address:No.123,Huixin Avenue,Huimin Dist
Hangzhou Haiqiang Chemical Co.,Ltd.
Contact:+86-571-86960370
Address:Add: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China
Doi:10.1021/acs.cgd.5b00621
(2015)Doi:10.1021/jo7022558
(2008)Doi:10.1021/acs.orglett.5b02522
(2015)Doi:10.1016/j.tetlet.2007.11.068
(2008)Doi:10.1021/acs.jpca.6b02767
(2016)Doi:10.1134/S1070428009100017
(2009)
