Synthesis of Some 6-Bromo-3-- and 2-Styryl-3--4(3H)-quinazolinones

Article abstract of DOI:10.1021/je00023a031

Some substituted 6-bromo-3-<(arylamino)methyl>-4(3H)-quinazolinones have been synthesized under the conditions of the Mannich reaction.In addition, a few unsubstituted and substituted 2-styryl-4(3H)-quinazolinones, 6-bromo-2-styryl-4(3H)-quinazolinones, and 6-bromo-2-styryl-3-<4'-(carboethoxy)phenyl>-4(3H)-quinazolinones have also been synthesized by condensing the corresponding 2-methyl derivative with an appropriate aromatic aldehyde.Representative compounds have been screened for their central neural system and antiviral activity.