ACETOFORMIC ANHYDRIDE IN THE SYNTHESIS OF CHROMONES. 1. SYNTHESIS OF 3-HETARYLCHROMONES

Article abstract of DOI:10.1007/BF00473991

It was shown that the reaction of α-(het)aryl-2,4-dihydroxy- and 2,4,6-trihydroxyacetophenones with acetoformic anhydride catalyzed by sodium formate is an effective method for the preparation of chromones containing a heteroaromatic residue at the 3-position.The yield of the chromone and the rate of the reaction increase with increase in the ?-deficiency of this residue or in the presence of a hydroxy group in the 6-position of the starting acetophenone.In the last case the method is also applicable to the preparation of the difficulty available 3-aryl-5,7-dihydroxychromones.Chromones with a nitrogen-containing residue are formed without the use of any catalyst.