Concomitant C(α),C(β)-Asymmetric Induction in the Aza-Claisen Rearrangement of N-Allylketene N,O-Acetals

Article abstract of DOI:10.1021/jo00359a001

Asymmetric C-C bond formation via the diastereoselective aza-Claisen rearrangement of N-allylketene N,O-acetals 4 is described.The starting materials, allylic alkylating agent 1 and optically pure oxazoline 2, are easily prepared and, in a one-pot procedu