Journal of Organic Chemistry p. 1541 - 1544 (1986)
Update date:2022-08-02
Topics:
Meyers, A. I.
Lefker, Bruce A.
An asymmetric synthesis of the title compounds has been achieved in >98percent ee using chiral bicyclic lactams 14 derived from (S)-valinol and γ-keto acids.Thus, cyclocondensation of racemic 2-p-tolyl-4-oxopentanoic acid with (S)-valinol gave a 1:1 mixtu
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