Formal total synthesis of fostriecin via 1,4-asymmetric induction using cobalt-alkyne complex

DOI: 10.1021/ol800195g

Source and publish data:

Organic Letters p. 1405 - 1408 (2008)

Update date:2022-07-29

Topics:

Authors:

Hayashi, Yujiro

Yamaguchi, Hirofumi

Toyoshima, Maya

Okado, Kotaro

Toyo, Takumi

Shoji, Mitsuru

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Article abstract of DOI:10.1021/ol800195g

(Chemical Equation Presented) The synthesis of a protected dephosphofostriecin, and thereby a formal synthesis of fostriecin, has been accomplished. Two of the four chiral centers are controlled by an external chiral auxiliary and the other two are synthesized stereoselectively, one by a novel 1,4-asymmetric induction using cobalt-alkyne complex, and the other by 1,3-asymmetric induction.

Full text of DOI:10.1021/ol800195g

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