Total Synthesis of (+)-Dihydromevinolin

DOI: 10.1021/ja00275a053

Source and publish data:

Journal of the American Chemical Society p. 4586 - 4594 (1986)

Update date:2022-08-04

Topics: NMR spectroscopy Catalyst Total synthesis Reagent Stereoselective Purification Substrate Chiral Auxiliary Chemical Reaction

Authors:

Hecker, Scott J.

Heathcock, Clayton H.

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Article abstract of DOI:10.1021/ja00275a053

A total syntheses of (+)-dihydromevinolin (2b) is presented, as well as the preparation of three analogues (62, 63, and 64) for assessment of their biological activity.Base-promoted fragmentation of the tosylhydrazone (20) of key intermediate 6 affords ac

Full text of DOI:10.1021/ja00275a053

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