Structural simplification of bioactive natural products with multicomponent synthesis. 2. Antiproliferative and antitubulin activities of pyrano[3,2-c]pyridones and pyrano[3,2-c]quinolones

DOI: 10.1021/jm701499n

Source and publish data:

Journal of Medicinal Chemistry p. 2561 - 2570 (2008)

Update date:2022-09-26

Topics:

Authors:

Magedov, Igor V.

Manpadi, Madhuri

Ogasawara, Marcia A.

Dhawan, Adriana S.

Rogelj, Snezna

Van Slambrouck, Severine

Steelant, Wim F. A.

Evdokimov, Nikolai M.

Uglinskii, Pavel Y.

Elias, Ecrik M.

Knee, Erica J.

Tongwa, Paul

Antipin, Mikhail Yu.

Kornienko, Alexander

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Article abstract of DOI:10.1021/jm701499n

Pyrano[3,2-c]pyridone and pyrano[3,2-c]quinolone structural motifs are commonly found in alkaloids manifesting diverse biological activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent sy

Full text of DOI:10.1021/jm701499n

Products guided by the article

Product name:4-(2-amino-3-cyano-6-methyl-5-oxo-5,6-dihydro-4H-pyrano[3,2-c]quinolin-4-yl)-2-bromo-6-methoxyphenyl acetate

Cas No:1019060-12-8

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