Bioorganic and Medicinal Chemistry Letters p. 1419 - 1424 (2008)
Update date:2022-08-03
Topics:
Zhou, Yuefen
Li, Lian-Sheng
Dragovich, Peter S.
Murphy, Douglas E.
Tran, Chinh V.
Ruebsam, Frank
Webber, Stephen E.
Shah, Amit M.
Tsan, Mei
Averill, April
Showalter, Richard E.
Patel, Rupal
Han, Qing
Zhao, Qiang
Hermann, Thomas
Kissinger, Charles R.
LeBrun, Laurie
Sergeeva, Maria V.
5-Hydroxy-3(2H)-pyridazinone derivatives were investigated as inhibitors of genotype 1 HCV NS5B polymerase. The structure-activity relationship (SAR) associated with variation of the pyridazinone 2- and 6-substituents is discussed. The synthesis and metab
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