ONE-STEP PROTECTION OF THE NUCLEOSIDE BASE IN THYMIDINE AND URIDINE

DOI: 10.1016/S0040-4039(00)89270-9

Source and publish data:

Tetrahedron Letters p. 3859 - 3862 (1985)

Update date:2022-09-26

Topics: Protection Thymidine Uridine One-step

Authors:

Claesen, C. A. A.

Pistorius, A. M. A.

Tesser, G. I.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)89270-9

Unprotected thymidine and uridine react with 4-nitrophenylsulfonyl ethene (3) in a base catalyzed Michael type addition to give O⁴-(4-nitrophenylsulfonylethyl)thymidine (6) and -uridine (7), respectively.The 4-nitrophenylsulfonylethyl group is cleaved within 2.5 hours at 50-55 deg C by concentrated aqueous ammonia, via β-elimination.

Full text of DOI:10.1016/S0040-4039(00)89270-9

Products guided by the article

Product name:O⁴-(4-nitrophenylsulfonylethyl)uridine

Cas No:102093-87-8

R&D Labs maybe for 102093-87-8

GenicBio Limited

Contact:+86-(0)21-3770 9035

Address:Room 301, Building 2, Meijiabang Road 1508, Shanghai China
Zhangjiagang Jianing Import & Export Co.,Ltd.

Contact:086-512-55379012 13913607595

Address:NO.1 Guotai North Road Zhangjiagang Economic Development Zone,215600,Jiangsu,China
MedicalChem(Yancheng)Manuf.Co.,Ltd.

Contact:+86-515-84383366

Address:Touzeng BinHai, YanCheng City, JiangSu Province, China
Changzhou LanXu Chemical Co.,ltd.(expird)

Contact:86-0519-86330911,13656129734,15261186386

Address:Room 524, Depart.Chemical, Changzhou Science and Eductaion town, Jiangsu, China;Factory: Haian Fine Chemical Industry Park,Nantong,Jiangsu,China
Junkai (Tianjin) Chemical Co., Ltd.

website:http://www.junkaichem.com

Contact:86-22-85689515

Address:Room 8-501, Building K2, The Hi-Tech Green Industrial Base, No.6, 6th Road, Hi-Tech Development Road, Tianjin Hi-Tech IndustrialPark, Tianjin, China.

Relevant to this article

Saturated Heterocycles, 75 - Preparation of Tetracyclic Thiophene Derivatives with Bridgehead Nitrogen. Synthesis of Polymethylenethieno<2,3-d>dihydropyrrolo-, tetrahydropyrido- and tetrahydroazepino<1,2-a>pyrimidin-4-ones and -4-thiones

Doi:10.1007/BF00810875
(1986)
A convenient approach to heterocyclic building blocks: Synthesis of novel ring systems containing a [5,6]pyrano[2,3-c]pyrazol-4(1H)-one moiety

Doi:10.3390/12010060
(2007)
Analysis of the pharmacokinetic/pharmacodynamic relationship of a small molecule CXCR3 antagonist, NBI-74330, using a murine CXCR3 internalization assay

Doi:10.1038/sj.bjp.0707519
(2007)
New chiral iodooxazoline catalysts for the I(III)-mediated α-tosyloxylation of ketones: Refining the stereoinduction model

Doi:10.1016/j.tetasy.2013.08.002
(2013)
Total synthesis of biologically important amino sugars via the nitroaldol reaction

Doi:10.1016/S0040-4039(00)94865-2
(1985)
Total synthesis of calonyctin A2, a macrolidic glycolipid with plant growth-promoting activity

Doi:10.1016/S0040-4039(00)00427-5
(2000)

Article Doi