Synthesis of γ- and δ-lactones from 1α-hydroxy-5,6-trans-vitamin D3 by ring-closing metathesis route and their reduction with metal hydrides

Article abstract of DOI:10.1016/j.steroids.2007.03.005

New synthetic pathway towards 19-functionalized derivatives of 1α-hydroxy-5,6-trans-vitamin D₃ was described. Ring-closing metathesis (RCM) of 1α-hydroxy-5,6-trans-vitamin D₃ 1-ω-alkenoates was a key-step. Hydride reduction of result