Synthesis, selective aldose reductase inhibitory profile and antihyperglycaemic potential of certain parabanic acid derivatives

Article abstract of DOI:10.3797/scipharm.aut-01-204

Synthesis and aldose reductase inhibitory profile of certain parabanic acid derivatives 1a-p is described. Also, the antihyperglycaemic potential of these compounds was studied. The most active inhibitors in this series were compounds 1 g, 1p, and 1o which showed inhibitory activity, 36.6, 90 and 91% respectively, at concentration 1 × 10^-4. Their IC₅₀ were 2 × 10^-6, 7.5 × 10^-8 and 5 × 10^-8, respectively. Compound 1o exhibited pronounced antihyperglycaemic effect.