Journal of the Chemical Society. Perkin transactions I p. 2909 - 2913 (1996)
Update date:2022-08-05
Topics:
Detsi, Anastasia
Bardakos, Vassilios
Markopoulos, John
Igglessi-Markopoulou, Olga
A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones, compounds of great biological importance, is described. The C-acylation of active methylene compounds 2 with the 2-methyl-3,1-benzoxazin-4-one 1, under basic conditions, leads to the formation of the new products 3-10, which have been isolated and characterized. Cyclization of the above intermediates furnishes the 3-substituted 4-hydroxyquinolin-2(1H)-ones. Spectral data and physical characteristics for all compounds are reported.
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