Enzymatic Asymmetrization of 6-Amino-2-cycloheptene-1,4-diol Derivatives: Synthesis of Tropane Alkaloids (+)- and (-)-Calystegine A3

Article abstract of DOI:10.1021/jo00108a025

6-Azido and 6-((tert-butyloxycarbonyl)amino)derivatives of meso-2-cycloheptene-1,4-diol were prepared from cycloheptatriene and asymmetrized using Pseudomonas cepacia lipase.Enantiopure intermediates thus prepared were used in the syntheses of both enanti