Chemical and Pharmaceutical Bulletin p. 1165 - 1168 (1998)
Update date:2022-07-30
Topics:
Miyachi, Hiroyuki
Koiso, Yukiko
Shirai, Ryuichi
Niwayama, Satomi
Liu, Jun O.
Hashimoto, Yuichi
The synthesis and tumor necrosis factor (TNF)-α production enhancing activity of substituted 3'-methyl-thalidomides on human leukemia cell line HL-60 stimulated with 12-O-tetradecanoyl-phorbol 13-acetate (TPA) are described. Though the introduction of an electron-donating amino group at the phthaloyl moiety of α-methylthalidomides enhanced the activity, substituted α-methylthalidomides showed decreased stereoselectivity as compared to that of non-substituted α-methylthalidomide. The data indicates that the TNF-α production enhancing activity of thalidomide derivatives depends on both the electronic-state of substituents at the fused benzene ring and the stereochemistry of the glutarimide moiety.
View MoreChangzhou BaoKang Pharmaceutical & Chemical Co., Ltd
Contact:(86) 519-88782201 88784080 88785278
Address:Henglin town, changzhou,Jiangsu
Ningbo Distant Chemicals Co.,Ltd
Contact:86-574-27862490,27862438
Address:5F-3,#54 DaShaNi street,Ningbo,CHINA
Tianjin Hedong Red Cliff Chemical Reagent Factory
Contact:+86-022-84780548
Address:Li Ming Zhuang Gong Ye Yuan,Dongli District,Tianjin,China
Daqing New Century Fine Chemical Co., Ltd.(expird)
Contact:010-57126694
Address:No.39, jinxing cun, honggang district
Wuhan Shangrisyn chemicals Technology Co.,Ltd(expird)
Contact:+86-027-84466317 __ +86-15387123698
Address:wuhan - china
Doi:10.1080/15533174.2013.809746
(2015)Doi:10.1016/0040-4039(94)88062-X
(1994)Doi:10.1016/j.bmcl.2018.04.026
(2018)Doi:10.1021/ja00275a044
(1986)Doi:10.1021/jm9606599
(1997)Doi:10.1016/S0040-4039(00)01197-7
(2000)