Diastereoselective Synthesis of Cis-3- And 3,5-Alkylpyrrolizidines

Article abstract of DOI:10.1002/jhet.5570350219

Cis-3 and 3,5-substituted pyrrolizidines can be prepared from β-enaminolactones. Substituted pyrrolidinoketones lead to these compounds by an amino reductive annelation with a low diastereomeric excess, but a best access to these azabicycles consists in preparing cis-2,5-disubstituted pyrrolidines which are then transformed into the expected heterocycles.