Synthesis and evaluation of novel thiazolidine derivatives as thromboxane A2 receptor antagonists

DOI: 10.1248/cpb.42.521

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 521 - 529 (1994)

Update date:2022-08-02

Topics:

Authors:

Sato Sato

Kawashima

Goto Goto

Yamane Yamane

Chiba Chiba

Jinno Jinno

Satake Satake

Imanishi

Iwata Iwata

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.521

A series of 3-benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were synthesized, and evaluated for their thromboxane A₂ (TXA₂) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α- (epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). A simple 2-arylthiazolidine derivative, 3- benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine (5a), showed mild TXA₂ receptor antagonist activity. Modification of 5a led to 2-chloro-4-[3-(4- chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyaretic acid (29d), which showed 10 times more potent TXA₂ receptor antagonist activity than 5a.

Full text of DOI:10.1248/cpb.42.521

NII-Electronic Library Service

Products guided by the article

Product name:Acetic acid 4-thiazolidin-2-yl-phenyl ester

Cas No:1026860-95-6

R&D Labs maybe for 1026860-95-6

Ningbo Huajia Chemicals

Contact:+86-574-87065746

Address:10th Floor, No.787 Baizhang East Road,
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Shandong Hongxiang Zinc Co., Ltd

Contact:086-0311-66187879

Address:DaWang developing zone
Anhui Sholon New Material Technology Co., Ltd.

website:http://www.sholonchem.com

Contact:+86-550-5261666

Address:4/F Block B, Beijing Chemical Building.No.520 Tianrun Road ,Science & Education Town Wujin District, Changzhou City Jiangsu Province
Suzhou Ryan Pharmachem Technology Co.,Ltd

Contact:+86-0512-68780025

Address:B-301,No.2 Taishan Road,Suzhou New District,Jiangsu,P.R. China

Relevant to this article

Doi:10.1177/000992280104000608
(1931)
Mesostructured vanadia-alumina catalysts for the synthesis of vitamin K₃

Doi:10.1016/j.cattod.2014.12.026
(2015)
Synthetic approach toward antibiotic tunicamycins. 3. Methyl 3,4,7,8-tetra-O-acetyl-10-O-benzyl-2-benzyloxycarbonylamino-2,6-dideoxy-11,12- O-isopropylidene-β-l-dodecodialdo-(12R)-furanose-(12,9)-pyranosides-(1,5)

Doi:10.1246/bcsj.55.1574
(1982)
[Ru(η³-2-C₃H₄Me)(CO)(dppf)][SbF ₆]: A mononuclear 16e^- ruthenium(II) catalyst for propargylic substitution and isomerization of HC≡CCPh₂(OH)

Doi:10.1039/b410812d
(2004)
Asymmetric synthesis of a prostaglandin D₂ receptor antagonist

Doi:10.1021/jo048305+
(2005)
Copper-mediated regio- and stereoselective 12β-hydroxylation of steroids with molecular oxygen and an unexpected 12β-chlorination

Doi:10.1016/j.tet.2004.10.055
(2005)

Article Doi