Synthesis and evaluation of novel thiazolidine derivatives as thromboxane A2 receptor antagonists

DOI: 10.1248/cpb.42.521

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 521 - 529 (1994)

Update date:2022-08-02

Topics:

Authors:

Sato Sato

Kawashima

Goto Goto

Yamane Yamane

Chiba Chiba

Jinno Jinno

Satake Satake

Imanishi

Iwata Iwata

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.521

A series of 3-benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were synthesized, and evaluated for their thromboxane A₂ (TXA₂) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α- (epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). A simple 2-arylthiazolidine derivative, 3- benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine (5a), showed mild TXA₂ receptor antagonist activity. Modification of 5a led to 2-chloro-4-[3-(4- chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyaretic acid (29d), which showed 10 times more potent TXA₂ receptor antagonist activity than 5a.

Full text of DOI:10.1248/cpb.42.521

NII-Electronic Library Service

Products guided by the article

Product name:Acetic acid 4-thiazolidin-2-yl-phenyl ester

Cas No:1026860-95-6

R&D Labs maybe for 1026860-95-6

QINGDAO DEVELOP chemistry Co.,Limited

Contact:+86-532-85807910

Address:98#Nanjing Road, Qingdao, China 266071
Nanjing lanbai chemical Co.,Ltd.

Contact:+86-25-85499326

Address:Room 908, 9F Taiyue Building,No.285 Heyan Road
LinHai Cina Chemical Co., LTD.

Contact:0576-85580989

Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Jiangsu Taihu New Materials Holding Co., Ltd

Contact:+86-519-86160108

Address:Xueyan Town, Changzhou City, Jiangsu Province, 213169, China
Chongqing Rong＆Quan Pharmaceutical Technology Co. , Ltd.

Contact:86-023-65268721

Address:No. 7, Manshanhong Village, Pingdingshan, Shapingba District, Chongqing Province, China

Relevant to this article

Doi:10.1177/000992280104000608
(1931)
Mesostructured vanadia-alumina catalysts for the synthesis of vitamin K₃

Doi:10.1016/j.cattod.2014.12.026
(2015)
Synthetic approach toward antibiotic tunicamycins. 3. Methyl 3,4,7,8-tetra-O-acetyl-10-O-benzyl-2-benzyloxycarbonylamino-2,6-dideoxy-11,12- O-isopropylidene-β-l-dodecodialdo-(12R)-furanose-(12,9)-pyranosides-(1,5)

Doi:10.1246/bcsj.55.1574
(1982)
[Ru(η³-2-C₃H₄Me)(CO)(dppf)][SbF ₆]: A mononuclear 16e^- ruthenium(II) catalyst for propargylic substitution and isomerization of HC≡CCPh₂(OH)

Doi:10.1039/b410812d
(2004)
Asymmetric synthesis of a prostaglandin D₂ receptor antagonist

Doi:10.1021/jo048305+
(2005)
Copper-mediated regio- and stereoselective 12β-hydroxylation of steroids with molecular oxygen and an unexpected 12β-chlorination

Doi:10.1016/j.tet.2004.10.055
(2005)

Article Doi