Journal of Antibiotics p. 1004 - 1012 (2001)
Update date:2022-08-03
Topics:
Momose, Isao
Sekizawa, Ryuichi
Hirosawa, Sehei
Ikeda, Daishiro
Naganawa, Hiroshi
Inuma, Hironobu
Takeuchi, Tomio
The structures of tyropeptins A and B, new proteasome inhibitors produced by Kitasatospora sp. MK993-dF2, were determined by analysis of various NMR experiments. The 1H and 13C NMR of tyropeptins were complicated due to the presence of an aldehyde group. Therefore, tyropeptins were converted to their alcohols by sodium borohydride. These alcohol derivatives gave assignable NMR spectra. The stereochemistry of tyropeptins were determined by analysis of acid hydrolysis products from tyropeptins, and further confirmed by the total synthesis. The structures of tyropeptins A and B were found to be isovaleryl-L-tyrosyl-L-valyl-DL-tyrosinal and n-butyryl-L-tyrosyl-L-leucyl-DL-tyrosinal, respectively.
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