Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp sequence of fibrinogen. (Aminobenzamidino)succinyl (ABAS) series of orally active fibrinogen receptor antagonists

DOI: 10.1021/jm00013a014

Source and publish data:

Journal of Medicinal Chemistry p. 2378 - 2394 (1995)

Update date:2022-08-03

Topics:

Authors:

Zablocki

Rico Rico

Garland Garland

Rogers Rogers

Williams

Schretzman

Rao Rao

Bovy Bovy

Tjoeng Tjoeng

Lindmark

Toth Toth

Zupec Zupec

McMackins

Adams Adams

Miyano Miyano

Markos Markos

Milton Milton

Paulson Paulson

Herin Herin

et al. et al.

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Article abstract of DOI:10.1021/jm00013a014

Our initial orally active fibrinogen receptor antagonist benzamidinopentanoyl (BAP) series which was discovered through truncation of our iv antiplatelet agent (SC-52012) demonstrated modest oral activity in canine studies (ethyl [5-(4-amidinophenyl)penta

Full text of DOI:10.1021/jm00013a014

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