Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists

DOI: 10.1021/jm00062a005

Source and publish data:

Journal of Medicinal Chemistry p. 1333 - 1342 (1993)

Update date:2022-07-29

Topics: Antagonist Pharmacophore Structure-activity relationships Chemical Structure Biological Activity Experimental Design

Authors:

Jacobson

Gallo-Rodriguez

Melman Melman

Fischer Fischer

Maillard

Van Bergen

Van Galen

Karton Karton

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00062a005

A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A₂-selective adenosine receptor antagonists, and the potency at rat brain A₁- and A₂-receptors was studied in radioligand bi

Full text of DOI:10.1021/jm00062a005

Products guided by the article

Product name:(E)-N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(3,5-difluoro-phenyl)-acrylamide

Cas No:1026807-55-5

R&D Labs maybe for 1026807-55-5

tianjin kailiqi biotechnology co.，ltd

Contact:+86-22-23754520

Address:Tianjin hi tech development in Xiqing District 2 Road No. 2 Building No. 5 414
Zhejiang Allied Chemical Co.,Ltd

Contact:18967038207

Address:Area A-30, High-tech Industrial Park, Quzhou, Zhejiang, China.
Wuhan Konberd Biotech Co., Ltd.

Contact:+86-27-87205925

Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Hangzhou Fortune Biopharm Co.,LTD.

website:http://www.ftpharm.com

Contact:86-571-87621708

Address:279 Zixuan Road,Xihu District,Hangzhou,Zhejiang(310030),China.
tianjin kailiqi biotechnology co.，ltd

Contact:+86-22-23754520

Address:Tianjin hi tech development in Xiqing District 2 Road No. 2 Building No. 5 414

Relevant to this article

Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes

Doi:10.1016/S0968-0896(00)00100-0
(2000)
Photoisomerization of the green fluorescence protein chromophore and the meta- and para-amino analogues

Doi:10.1039/b717714c
(2008)
Synthesis of dipeptide isosteres by cross-metathesis

Doi:10.1016/j.tet.2012.06.004
(2012)
A simple one-pot method for the synthesis of partially protected mono- and disaccharide building blocks using an orthoesterification-benzylation-orthoester rearrangement approach

Doi:10.1016/S0008-6215(03)00349-5
(2003)
Dual cobalt-copper light-driven catalytic reduction of aldehydes and aromatic ketones in aqueous media

Doi:10.1039/c7sc01276d
(2017)
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors

Doi:10.1016/j.bmcl.2008.03.021
(2008)

Article Doi