Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists

DOI: 10.1021/jm00062a005

Source and publish data:

Journal of Medicinal Chemistry p. 1333 - 1342 (1993)

Update date:2022-07-29

Topics: Antagonist Pharmacophore Structure-activity relationships Chemical Structure Biological Activity Experimental Design

Authors:

Jacobson

Gallo-Rodriguez

Melman Melman

Fischer Fischer

Maillard

Van Bergen

Van Galen

Karton Karton

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Article abstract of DOI:10.1021/jm00062a005

A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A₂-selective adenosine receptor antagonists, and the potency at rat brain A₁- and A₂-receptors was studied in radioligand bi

Full text of DOI:10.1021/jm00062a005

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