Journal of the Chemical Society. Perkin transactions I p. 2845 - 2850 (1996)
Update date:2022-07-29
Topics:
Gilmore, Jeremy
Prowse, Will
Steggles, David
Urquhart, Michael
Olkowski, Jennifer
The multigram synthesis of (2S)- and (2R)-2-(1-methylethyl)-5-oxo-2-phenylpentanenitriles 9a and 9b is described, using either (4,R)-2,2-dimethyl-1,3-dioxolan-4-ylmethanol or (2R)-butane-1,2,4-triol as chiral auxiliary. The configuration of an intermediate dioxolane 10b is assigned by X-ray crystallography. The synthetic utility of the aldehydes is demonstrated by conversion to both enantiomers of the calcium antagonist noremopamil in >98% enantiomeric excess (ee). The enantiomeric purity of the final amines is assayed by 1H NMR spectroscopy in the presence of the chiral solvating agent (1R)-(-)-2,2,2-trifluoro-1-(9-anthryl)ethanol.
View MoreDalian Join King Biochemical Tech. Co., Ltd.
Contact:0411 39216206
Address:814 First State Blvd
Jiaxing Anrui Material Technology Co., Ltd.
Contact:86-573-82651652 13305832579
Address:Room 407, Technology Building, 1369 Chennan Road, Jiaxing City, Zhejiang, China
RongCheng K&S Chemical Co.,Ltd
Contact:0631-7336369
Address:rongcheng ,shandong province china
Jiangsu Hualun Chemical Industry Co., Ltd
website:http://www.hualunchem.com
Contact:+86-0514-86464168 86507985
Address:39# Middle Renmin Road, Dinghuo Town
Ningxia Soochow Agrochemical Limited Company
Contact:(+86）0512 6320 8190
Address:wujiang
Doi:10.1021/ja01516a039
(1959)Doi:10.1021/cg2002628
(2011)Doi:10.1080/00397910903221753
(2010)Doi:10.1039/b507401k
(2005)Doi:10.1021/ja8015632
(2008)Doi:10.1021/ja800830h
(2008)
