Synthesis of (Z)-3-(2-hydroxybutylidene)phthalide

Article abstract of DOI:10.1080/00397919408011328

The first synthesis of (Z)-3-(2-hydroxybutylidene)phthalide (1) is described, starting from phthalic anhydride (2). The key step in the synthesis is the condensation of the kinetic lithium enolate of butanone with 2.

Full text of DOI:10.1080/00397919408011328

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Synthesis of (Z)-3-(2-
Hydroxybutylidene)phthalide
Zhiwei Wang a , Shaobai Li a , Fulin Yan a b & Yulin Li
a
a State Key Laboratory of Applied Organic Chemistry
and Institute of Organic Chemistry, Lanzhou
University , Lanzhou, 730000, P. R. China
b Department of Chemistry , Xinxiang Medical
College
Published online: 23 Sep 2006.
To cite this article: Zhiwei Wang , Shaobai Li , Fulin Yan & Yulin Li (1994) Synthesis
of (Z)-3-(2-Hydroxybutylidene)phthalide, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 24:21, 3135-3139,
DOI: 10.1080/00397919408011328
To link to this article: http://dx.doi.org/10.1080/00397919408011328
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