Bioorganic and Medicinal Chemistry Letters (2020)
Update date:2022-08-05
Topics:
Ding, Zichao
Ni, Tingjunhong
Xie, Fei
Hao, Yumeng
Yu, Shichong
Chai, Xiaoyun
Jin, Yongsheng
Wang, Ting
Jiang, Yuanying
Zhang, Dazhi
The incidence of invasive fungal infections has dramatically increased for several decades. In order to discover novel antifungal agents with broad spectrum and anti-Aspergillus efficacy, a series of novel triazole derivatives containing 1,2,3-benzotriazin-4-one was designed and synthesized. Most of the compounds exhibited stronger in vitro antifungal activities against tested fungi than fluconazole. Moreover, 6m showed comparable antifungal activity against seven pathogenic strains as voriconazole and albaconazole, especially against Aspergillus fumigatus (MIC = 0.25 μg/ml), and displayed moderate antifungal activity against fluconazole-resistant strains of Candida albicans. A clear SAR study indicated that compounds with groups at the 7-position resulted in novel antifungal triazoles with more effectiveness and a broader-spectrum.
View MoreHANGZHOU EVC CHEMICAL CO.,LTD.(expird)
Contact:+86-571-88296056
Address:Room#3001,Zhejiang Chemical Market,No.10,Road Shenban,Hangzhou,Zhejiang,China
Weifang Jahwa Chemical Co.,Ltd
Contact:0086-536-8897731,8897730
Address:No.5166 East Dongfeng Street,Weifang,Shandong,China
LIAOYANG TENGYUAN FOOD ADDITIVE FACTORY
Contact:+86-419-5807666
Address:Haodianzi village,Hanling Town,Liaoyang county
He Bei Shun Er Chemical Co., LTD.
Contact:86-0311-86996932/86860168
Address:No 18,North street
Tianjin Ingenochem Technology Co.,Ltd
Contact:+86-22-23677060
Address:Hitech Green Industry Park K2-9-602, Nankai district
Doi:10.1002/anie.200904694
(2009)Doi:10.1007/s10600-015-1268-x
(2015)Doi:10.1246/bcsj.79.1941
(2006)Doi:10.1007/s10593-007-0082-1
(2007)Doi:10.1016/j.tetlet.2008.03.030
(2008)Doi:10.1016/S0040-4039(00)98747-1
(1985)