Journal of Medicinal Chemistry p. 2085 - 2089 (1994)
Update date:2022-07-30
Topics:
Harfenist, Morton
Joyner, Charles T.
Mize, Patrick D.
White, Helen L.
Monoamine oxidase (MAO) exists in two forms distinguishable by substrate specificity.Inhibition of MAO A is believed to be responsible for the antidepressant activity of MAO inhibitors.A group of N-arylacetamides are highly specific inhibitors of MAO A, some with IC50 values in the 10-100 nM range.The requirements for high activity and specificity include a nearly linear tricyclic aromatic portion but a larger and a smaller central ring component.The amide group, which is best acetamido, is optimally placed para to the smaller central group.The size and shape of the aromatic moiety appear to be the major influence on activity and specificity for MAO A.
View MoreHangzhou Deli Chemical Co.,Ltd.
website:http://www.dlchemical.com
Contact:86 571 28006267
Address:Tangxi Industrial Area, Yuhang District, Hangzhou
Contact:+86-021-50792271
Address:Building 24A, 300 Chuantu Road, Chuansha, Pudong new area, Shanghai, China, 201202
Geen Chemical Technology Co., Ltd
Contact:86-769-21660847
Address:1408, Yingfeng Commercial Center, Nancheng District
Contact:0086 371 65711996
Address:Jalan 4/3, Kawasan Perindustrian Serendah, 48000 Rawang,
Zhejiang Quzhou Jiancheng Silicone Co., Ltd.(Shanghai Jiancheng Industial and Trade Co, Ltd)
Contact:18957018777 +86-570-3888777
Address:The company production base address： Quzhou City, Zhejiang Province high-tech industrial park Nianhua Road 37
Doi:10.1021/acs.orglett.1c01117
(2021)Doi:10.1021/ja01362a033
(1931)Doi:10.1021/jo00368a005
(1986)Doi:10.1021/jo8003953
(2008)Doi:10.1002/hlca.19600430612
(1960)Doi:10.1016/j.chemphys.2011.02.013
(2011)
