Cacospongione A, Cacospongienone A, and Cacospongienone B, New C21 Difuran Terpenoids from the Marine Sponge Cacospongia scalaris SCHMIDT of the Cote d'Azur

Article abstract of DOI:10.1002/hlca.19860690325

The sponge Cacospongia scalaris (family Thorectidae), collected at the Cap de Nice (Cote d'Azur), is shown to contain a series of truncated, linear C21 difuran terpenoids comprising the known sponge products furospongin-1 ((+)-1), furospongin-2 (2), and dihydrofurospongin-2 ((-)-(E)-3), besides te new products cacospongione A ((-)-4), cacospongienone A ((-)-(Z)-6), and cacospongienone B ((-)-(E)-6), whose absolute configurations have been assigned by chemical correlations with (+)-1.Possibly, one of the two cacospongienones is an artifact, as these two terpenoids interconvert on standing.This is the first finding of linear C21 difuran terpenoids, which are typical of the Spongiidae, in a member of the family Thorectidae.