Extra binding region induced by non-zinc chelating inhibitors into the S1 subsite of matrix metalloproteinase 8 (MMP-8)

DOI: 10.1021/jm801166j

Source and publish data:

Journal of Medicinal Chemistry p. 1040 - 1049 (2009)

Update date:2022-08-04

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Authors:

Pochetti, Giorgio

Montanari, Roberta

Gege, Christian

Chevrier, Carine

Taveras, Arthur G.

Mazza, Fernando

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Article abstract of DOI:10.1021/jm801166j

The mode of binding and the activity of the first two non-zinc chelating, potent, and selective inhibitors of human neutrophil collagenase are reported. The crystal structures of the catalytic domain of MMP-8, respectively complexed with each inhibitor, r

Full text of DOI:10.1021/jm801166j

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