Bioorganic and Medicinal Chemistry Letters p. 2580 - 2584 (2008)
Update date:2022-09-26
Topics:
Andrews, David M.
Stokes, Elaine S.E.
Carr, Greg R.
Matusiak, Zbigniew S.
Roberts, Craig A.
Waring, Michael J.
Brady, Madeleine C.
Chresta, Christine M.
East, Simon J.
A lead benzamide, 3, was identified as a potent and low molecular weight histone deacetylase (HDAC) inhibitor. Optimization led to 16d, demonstrating an excellent balance of efficacy and non-efficacy properties, along with very desirable in vivo DMPK. The
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