Folate Analogues. 26. Syntheses of Antifolate Activity of 10-Substituted Derivatives of 5,8-Dideazafolic Acid and of the Poly-γ-glutamyl Metabolites of N10-Propargyl-5,8-Dideazafolic Acid (PDDF)

DOI: 10.1021/jm00159a032

Source and publish data:

Journal of Medicinal Chemistry p. 1754 - 1760 (1986)

Update date:2022-08-05

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Authors:

Nair, M.G.

Nanavati, Nitin T.

Nair, Indira G.

Kisliuk, Roy L.

Gaumont, Y.

et al. et al.

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Article abstract of DOI:10.1021/jm00159a032

The poly-γ-glutamyl derivatives of N¹⁰-propargyl-5,8-dideazafolic acid (PDDF) with a chain length of up to five glutamate residues were synthesized from N¹⁰-propargyl-5,8-dideazapteroic acid (7) by the solid-phase procedure.These com

Full text of DOI:10.1021/jm00159a032

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