PARTIAL PROTECTION OF CARBOHYDRATE DERIVATIVES. PART 18. SIMPLE, PREPARATIVE PROCEDURE FOR 5'-O-ACYLRIBONUCLEOSIDES; HIGHLY REGIOSELECTIVE O-DEACyLATION AT 2' AND 3' POSITIONS OF FULLY ACYLATED PURINE AND PYRIMIDINE RIBONUCLEOSIDE THROUGH SODIUM METHOXYDE-THF SYSTEM

Article abstract of DOI:10.1016/S0040-4020(01)91350-X

A treatment of fully acylated purine and pyrimidine ribonucleosides with a small excess amount of sodium methoxide in THF at room temperature gave the corresponding 5'-acylates in excellent yields; N-acyl groups on the nucleic acid base moieties of adenosine and cytidine in addition to guanosine derivatives satisfactorily survived under the conditions used.