Cyclic analogues of 2-amino-4-phosphonobutanoic acid (APB) and their inhibition of hippocampal excitatory transmission and displacement of [3H]APB binding

Article abstract of DOI:10.1021/jm00160a031

Conformationally restricted analogues of 2-amino-4-phosphonobutanoic acid (APB) were prepared where the structure of APB was incorporated into cyclopentane (3) or cyclohexane (4) rings. Hydrophosphinylation of the appropriate cycloalkenones followed by St