ASYMMETRIC REDUCTION OF PROCHIRAL HYDROXY KETONES WITH A CHIRAL REDUCING AGENT PREPARED FROM TIN(II) CHLORIDE, A CHIRAL DIAMINE, AND DIISOBUTYLALUMINUM HYDRIDE

Article abstract of DOI:10.1246/cl.1985.1359

Asymmetric reduction of prochiral α- and β-hydroxy ketones with a reagent, generated from tin(II) chloride, a chiral diamine, and diisobutylaluminum hydride, afforded the corresponding dihydroxy compounds in good chemical and optical yields.Optical yields depended on the nature of the protective groups of hydroxyl function.